CardioVascular and Interventional Radiology

, Volume 40, Issue 8, pp 1169–1175 | Cite as

Evaluation of Changes in Sexual Function Related to Uterine Fibroid Embolization (UFE): Results of the EFUZEN Study

  • Hélène Vernhet KovacsikEmail author
  • Denis Herbreteau
  • Sébastien Bommart
  • Jean-Paul Beregi
  • Jean-Michel Bartoli
  • Marc Sapoval
  • The French Society of Interventional and cardiovascular Imaging (SFICV) research group
Clinical Investigation



The main goal of the study was to evaluate sexual function before and one year after UFE. The secondary goals were to evaluate the quality of life before and one year after UFE and to determine the relation of imaging findings (MRI data) before and 3–6 months after UFE to changes in sexual function and quality of life.

Materials and Methods

Study design: a prospective, multicenter (25 centers) observational study was conducted. Patients: a total of 264 consecutive symptomatic women undergoing UFE using Embozene® (Celonova) from March 2012 to May 2013 were enrolled. Clinical data: the sexual function score and the quality of life score were calculated using the previously validated Female Sexual Function Index (FSFI) by Rosen and UFS-QOL by Spies, respectively, before and one year after UFE. Imaging data: MRI were performed before and 3–6 months after UFE. Data recorded were uterine and main fibroid volume, percentage of fibroid enhancement after injection of gadolinium. Impact of imaging data before and after UFE FSFS scores and QOL scores after UFE was searched.


Complete FSFI study and QOL study were obtained in 170 and 192 women, respectively. At 1 year post-UFE, improvement of FSFI score was seen in 134/170 women (78.8%), QOL scores were improved in 183/203 women (90.2%) and symptoms severity in 163/192 (84.9%). The relation between main fibroid reduction, decrease of fibroid enhancement and global UFS-QOL and FSFI scores was not established.


At one year post-embolization, UFE significantly improves all aspects of sexual function and quality of life.


Uterine fibroid embolization Quality of life Uterine arteries 


Centers Included in SFICV Study

H Vernhet-Kovacsik, CHU Arnaud de Villeneuve, Montpellier; J M Bartoli, AP-HM Hôpital Timone, CHU Marseille; J P Beregi, CHU Carémeau, Nîmes; F Boudghene, CH Gaston Ramon, Sens; P Chabrot, CHU Gabriel Montpied, Clermont-Ferrand; J C Brichaux, Clinique St Etienne, Bayonne; P Chevallier, Hôpital Archet II, CHU Nice; F Cotton, HCL, CHU Lyon Sud; M C Delchier, Hôpital Rangueil, CHU Toulouse; D Herbreteau, CHU Bretonneau, Tours; D Higue, CH Côte Basque, Bayonne; X Kos, Clinique Aressy, Bizanos; D Krause, Hôpital Bocage, CHU Dijon; J C Lasalarie, CHU Sud Réunion; M Lebbadi, CHU Fort de France; J Massonnat, Clinique Axium, Aix-en-Provence; C Poey, Clinique St Paul, Fort de France; P Romy, Clinique Pasteur, Guilherand Granges; G Roumieux, CH Henri Duffaut, Avignon; M Sapoval, AP-HP HEGP, CHU Paris; C Sengel, Hôpital Michallon, CHU Grenoble; F Thouveny, Hôpital Larrey, CHU Angers; H Trillaud, Hôpital St André, CHU Bordeaux; E Uzan, CHP Beauregard, Marseille; O Vignaux, AP-HP Hôpital Cochin, CHU Paris.

Compliance with Ethical Standards

Conflict of interest



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Copyright information

© Springer Science+Business Media New York and the Cardiovascular and Interventional Radiological Society of Europe (CIRSE) 2017

Authors and Affiliations

  • Hélène Vernhet Kovacsik
    • 1
    Email author
  • Denis Herbreteau
    • 2
  • Sébastien Bommart
    • 1
  • Jean-Paul Beregi
    • 3
  • Jean-Michel Bartoli
    • 4
  • Marc Sapoval
    • 5
  • The French Society of Interventional and cardiovascular Imaging (SFICV) research group
    • 6
  1. 1.Department of Interventional and Cardiovascular Imaging, Hospital Arnaud de VilleneuveCHU MontpellierMontpellierFrance
  2. 2.CHU ToursToursFrance
  3. 3.CHU NîmesNîmesFrance
  4. 4.APHM MarseilleMarseilleFrance
  5. 5.APHP ParisParisFrance
  6. 6.C.H.U. Rangueil (Service de Radiologie)Toulouse Cedex 4France

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