Short- and Long-Term (10-year) Results of an Organized, Population-Based Breast Cancer Screening Program: Comparative, Observational Study from Hungary
A nationwide breast cancer screening program was introduced in Hungary in the year 2002 for women aged 45–65 years to be performed biannually.
To investigate and report the short-term and 10-year follow-up results, we analyzed our Breast Unit’s prospectively led database of screened (Group A) and age-matched symptomatic (Group B) patients from 2002 to 2007. We compared the clinicopathologic features of tumors and the impact of screening on surgical treatment, as well as the overall (OS), disease-specific (DSS) and disease-free survival (DFS) of different groups.
Data from 208 screen-detected and 101 symptomatic patients between 45 and 65 years of age were examined. Screen-detected women were younger (54 vs. 58.5 years; p = 0.001) had significantly smaller tumors (15.5 vs. 17 mm; p = 0.044), and more breast-conserving surgery (68.8 vs. 59.4%; p = 0.032). Survival statistics were not statistically different at the median follow-up of 123 months; however, there was a trend toward improved DFS in Group A (82.7 vs. 74.3%; p = 0.074).
Our study showed a significant reduction in rates of mastectomy in the screen-detected group in the short term, which does not translate into better survival rates based on initial long-term data. In order to realize the real advantage of this newly enstated screening program, a longer period of investigation is needed.
Compliance with ethical standards
Conflict of interest
The authors declare that they have no conflict of interest.
- 3.WHO Position Paper on Mammography Screening (2014) World Health Organization, Geneva. Available from: https://www.ncbi.nlm.nih.gov/books/NBK269545/
- 5.Sobin LH, Gospodarowicz MK, Wittekind C (2011) TNM classification of malignant tumours. Wiley, OxfordGoogle Scholar
- 6.Újhelyi M, Pukancsik D, Kelemen P et al (2017) Reasons of non-attendance for organized breast cancer screening programme in Hungary—questionnaire of 3313 cases. Magy Seb 70(2):183Google Scholar
- 16.Gøtzsche PC, Jørgensen KJ (2013) Screening for breast cancer with mammography. Cochrane Database Syst Rev 6:CD001877Google Scholar