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Depression Induced by Total Mastectomy, Breast Conserving Surgery and Breast Reconstruction: A Systematic Review and Meta-analysis

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A Correction to this article was published on 26 March 2018

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Abstract

Background

To carry out a systematic review and meta-analysis of the literature to determine whether different type of surgery induces different depression occurrence in female breast cancer at mean time more than 1-year term postoperatively.

Methods

A systematic literature search of PubMed, Web of Science, EMBASE, OvidSP, EBSCO and PsycARTICLES was conducted. Observational clinical studies that compared the depression incidence in different surgery groups and presented empirical findings were selected.

Results

Sixteen studies met the inclusion criteria, including 5, 4, 2 and 5 studies compared depression between total mastectomy (TM) and breast conserving therapy (BCS), TM and breast reconstruction (BR), BCS and BR, or among all three groups (TM, BCS and BR), respectively. Only 1 of 5 studies, which subjected to multivariate analysis of depression in female breast cancer, reported a statistically significant effect of type of surgery on depression occurrence. Our meta-analysis showed no significant differences among the three types of surgery, with BCS patients versus TM patients (relative risk [RR] = 0.89, 95% confidence interval [CI] 0.78–1.01; P = 0.06), BR patients versus TM patients (RR = 0.87, 95% CI 0.71–1.06; P = 0.16) and BCS patients versus BR patients (RR = 1.10; 95% CI 0.89–1.35; P = 0.37), respectively.

Conclusions

Our study showed that there were no statistically significant differences concerning the occurrence of depressive symptoms in breast cancer patients as a consequence of TM, BCS or BR at mean time more than 1-year term postoperatively.

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Change history

  • 26 March 2018

    The following grant funding information was omitted from the original article.

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Acknowledgements

Grant support for the research reported: General Scientific Research foundation of Shanghai Mental Health Center Grants 2017-YJ-10; Youth Fundation of Zhongshan Hospital Grants 2016ZSQZ54.

Author information

Author notes

  1. Chengjiao Zhang and Guangfu Hu have contributed equally to this work and are co-first authors.

Authors and Affiliations

  1. Department of Psychological Measurement, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Chengjiao Zhang & Haiyin Zhang

  2. Department of Psychiatry, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Haiyin Zhang

  3. Department of Breast Surgery, Shanghai Huangpu District Central Hospital, Shanghai, China

    Guangfu Hu

  4. Department of General Surgery, Zhongshan Hospital, Fudan University, Shanghai, China

    Hongwei Zhang

  5. Shanghai University of Medicine and Health Sciences, Shanghai, China

    Ewelina Biskup

  6. Department of Internal Medicine, University Hospital of Basel, University of Basel, Basel, Switzerland

    Ewelina Biskup

  7. Medical School Library, Shanghai Jiao Tong University School of Medicine, Shanghai, China

    Xiaochun Qiu

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  1. Chengjiao Zhang
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Correspondence to Hongwei Zhang or Haiyin Zhang.

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Zhang, C., Hu, G., Biskup, E. et al. Depression Induced by Total Mastectomy, Breast Conserving Surgery and Breast Reconstruction: A Systematic Review and Meta-analysis. World J Surg 42, 2076–2085 (2018). https://doi.org/10.1007/s00268-018-4477-1

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