Abstract
We clarified the indication of partial hepatectomy in hepatocellular carcinoma (HCC) patients with liver cirrhosis classified as Child-Pugh class B. Univariate analysis revealed that adverse prognostic factors were (1) the presence of ascites, (2) elevated total bilirubin (1.5 mg/dl or higher), (3) reduced choline esterase (160 IU/ or lower), (4) elevated alpha-fetoprotein (AFP) (400 ng/ml or higher), (5) microscopic vascular invasion, and (6) non-curative hepatectomy. Microvascular invasion was excluded in the multivariate analysis because this factor could not be predicted before hepatectomy. Multivariate analysis revealed that independent adverse prognostic factors were (1) elevated total bilirubin (1.5 mg/dl or higher), (2) presence of ascites, (3) elevated AFP (400 ng/ml or higher), and (4) non-curative hepatectomy. The overall 5-year survival rate of patients with none of or only one of the four adverse prognostic factors was 45.8%. The overall 5-year survival rate of patients with two or more adverse prognostic factors was only 7.0%. Partial hepatectomy is the first choice of treatment for patients with none of or only one of the four adverse prognostic factors, whereas orthotopic liver transplantation or other conservative treatment should be considered for patients with two or more adverse prognostic factors.
Similar content being viewed by others
References
S Arii Y Yamaoka S Futagawa et al. (2000) ArticleTitleResults of surgical and nonsurgical treatment for small-sized hepatocellular carcinomas: a retrospective and nationwide survey in Japan Hepatology 32 1224–1229 Occurrence Handle10.1053/jhep.2000.20456 Occurrence Handle11093728
V Mazzaferro E Regalia R Doci et al. (1996) ArticleTitleLiver transplantation for the treatment of small hepatocellular carcinoma in patients with cirrhosis N. Eng. J. Med. 334 693–699 Occurrence Handle10.1056/NEJM199603143341104
H Bismuth PE Majno R. Adam (1999) ArticleTitleLiver transplantation for hepatocellular carcinoma Semin. Liver Dis. 19 311–322 Occurrence Handle10518310
JM Llovet J Fuster J. Bruix (1999) ArticleTitleIntention-to-treat analysis of surgical treatment for early hepatocellular carcinoma: resection versus transplantation Hepatology 39 1434–1440 Occurrence Handle10.1002/hep.510300629
S Kaihara T Kiuchi M Ueda et al. (2003) ArticleTitleLiving-donor liver transplantation for hepatocellular carcinoma Transplantation 75 S37–S40 Occurrence Handle10.1097/01.TP.0000047029.02806.16 Occurrence Handle12589138
J. Bruix (1997) ArticleTitleTreatment of hepatocellular carcinoma Hepatology 5 259–262
JN Vauthey D Klimstra D Franceschi et al. (1995) ArticleTitleFactor affecting long-term outcome after hepatic resection for hepatocellular carcinoma Am. J. Surg. 169 28–35 Occurrence Handle10.1016/S0002-9610(99)80106-8 Occurrence Handle7817995
Y Sasaki S Imaoka S Masutani et al. (1992) ArticleTitleInfluence of coexisting cirrhosis on long-term prognosis after surgery in patients with hepatocellular carcinoma Surgery 112 515–521 Occurrence Handle1325673
InstitutionalAuthorNameLiver Cancer Study Group of Japan (2003) General Rules for the Clinical and Pathological Study of Primary Liver Cancer Kanehara & Co., Ltd Tokyo 2–28
RNH Pugh IM Murray-Lyon JL Dawson et al. (1973) ArticleTitleTransection of the oesophagus for bleeding oesophageal varices Br. J. Surg. 60 646–649 Occurrence Handle4541913
C. Couinaud (1954) ArticleTitleLobe et segments hepatiques Presse Med. 62 709–712 Occurrence Handle13177441
AS Befeler AM. Di Bisceglie (2002) ArticleTitleHepatocellular carcinoma: diagnosis and treatment Gastroenterology 122 1609–1619 Occurrence Handle10.1053/gast.2002.33411 Occurrence Handle12016426
N Nagasue H Kohno M Tachibana et al. (1999) ArticleTitlePrognostic factors after hepatic resection for hepatocellular carcinoma associated with Child-Turcotte class B and C cirrhosis Ann. Surg. 229 84–90 Occurrence Handle10.1097/00000658-199901000-00011 Occurrence Handle9923804
S Ueno G Tanabe K Nuruki et al. (2002) ArticleTitlePrognosis of hepatocellular carcinoma associated with Child class B and C cirrhosis in relation to treatment: a multivariate analysis of 411 patients at a single center J. Hepatobiliary Pancreat. Surg. 9 469–477 Occurrence Handle10.1007/s005340200058 Occurrence Handle12483269
K Shirabe T Kanematsu T Matsumata et al. (1991) ArticleTitleFactors linked to early recurrence of small hepatocellular carcinoma after hepatectomy: univariate and multivariate analyses Hepatology 14 802–805 Occurrence Handle1657754
N Nagasue M Uchida Y Makino et al. (1993) ArticleTitleIncidence and factors associated intrahepatic recurrence after following resection of hepatocellular carcinoma Gastroenterology 105 488–494 Occurrence Handle8392955
S Okada K Shimada J Yamamoto et al. (1994) ArticleTitlePredictive factors for postoperative recurrence of hepatocellular carcinoma Gastroenterology 106 1618–1624 Occurrence Handle8194710
J Yamamoto T Kosuge T Takayama et al. (1996) ArticleTitleRecurrence of hepatocellular after surgery Br. J. Surg. 83 758–761 Occurrence Handle10.1046/j.1365-2168.1996.02342.x Occurrence Handle8696732
J Fuster JC Garcia-Valdecasas L Grande et al. (1996) ArticleTitleHepatocellular carcinoma and cirrhosis: results of surgical treatment in a European series Ann. Surg. 223 297–302 Occurrence Handle10.1097/00000658-199603000-00011 Occurrence Handle8604911
A Mazziotti GL Grazi A. Cavellari (1998) ArticleTitleSurgical treatment of hepatocellularcarcinoma on cirrhosis: a Western experience Hepatogastroenterology 45 1281–1287 Occurrence Handle9730389
PE Majno FP Sarasin G Mentha et al. (2000) ArticleTitleA Primary liver resection and salvage transplantation or primary transplantation in patients with single, small hepatocellular carcinoma and preserved liver function: an outcome-oriented decision analysis Hepatology 31 899–905 Occurrence Handle10.1053/he.2000.5763 Occurrence Handle10733546
J Bruix JM. Llovet (2002) ArticleTitlePrognostic prediction and treatment strategy in hepatocellular carcinoma Hepatology 35 519–524 Occurrence Handle10.1053/jhep.2002.32089 Occurrence Handle11870363
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Nakahara, H., Itamoto, T., Katayama, K. et al. Indication of Hepatectomy for Cirrhotic Patients with Hepatocellular Carcinoma Classified as Child-Pugh Class B. World J. Surg. 29, 734–738 (2005). https://doi.org/10.1007/s00268-005-7750-z
Published:
Issue Date:
DOI: https://doi.org/10.1007/s00268-005-7750-z