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Sir,
We read with great interest the article entitled “Effects of Insulin, Metoprolol and Deferoxamine on Fat Graft Survival” by Okyay et al. [1] in Aesthetic Plastic Surgery. The authors found that the three drugs did not exert a significant influence on fat graft survival.
The fat grafts treated with three kinds of drugs and the control group were implanted into the back of the rat. We are concerned that implanting different drugs on the back of one rat would result in drug absorption by the body and interfere with other groups.
In this study, the inguinal fat pads were split into four nearly equal parts as grafts. However, there would be a larger contact area between the grafts and the drug if the grafts were dissected into small pieces. Both shredded fat grafts and fat mass transplantation have been reported in the literature [2, 3], whose outcome may be different.
References
Okyay MF, Kömürcü H, Bağhaki S et al (2019) Effects of insulin, metoprolol and deferoxamine on fat graft survival. Aesthet Plast Surg 43(3):845–852
Liu K, Cai J, Li H et al (2018) The disturbed function of neutrophils at the early stage of fat grafting impairs long-term fat graft retention. Plast Reconstr Surg 142(5):1229–1238
Shi N, Su Y, Guo S et al (2019) Improving the retention rate of fat grafts in recipient areas via botulinum toxin A treatment. Aesthet Surg J. https://doi.org/10.1093/asj/sjz073
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Jin, S., Li, Y., Shang, T. et al. Several Opinions on Effects of Insulin, Metoprolol and Deferoxamine on Fat Graft Survival. Aesth Plast Surg 43, 1412 (2019). https://doi.org/10.1007/s00266-019-01413-6
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DOI: https://doi.org/10.1007/s00266-019-01413-6