Aesthetic Plastic Surgery

, Volume 42, Issue 4, pp 1170–1171 | Cite as

Letter to the Editor Regarding: Fleming D, Stone J, Tansley P. Spontaneous Regression and Resolution of Breast Implant-Associated Anaplastic Large Cell Lymphoma: Implications for Research, Diagnosis and Clinical Management. Aesth Plast Surg, 2018

  • Roberto N. Miranda
  • Mark W. Clemens
Letter to the Editor

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Dear Editor,

We read with interest the report of two cases by Dr. Fleming et al. purported to be “spontaneous regression” (case 1) and “spontaneous resolution” (case 2) of breast implant-associated anaplastic large cell lymphoma (BIA-ALCL) [1]. In the acknowledgements, the authors note a secondary pathology review was performed at MD Anderson Cancer Center by one of the authors (RNM) undersigned of this letter. Several contentions were asserted by the authors that we feel should be addressed and clarified.

Regarding case 1 highlighted as “spontaneous regression,” we reviewed the cytologic specimens obtained at three time points, January, March, and April, the latter one at the time of capsulectomy. The tumor burden was high in...


Compliance with Ethical Standards

Conflict of interest

None of the authors have any relevant financial relationships or affiliations to disclose.


  1. 1.
    Fleming D, Stone J, Tansley P (2018) Spontaneous regression and resolution of breast implant-associated anaplastic large cell lymphoma: implications for research, diagnosis and clinical management. Aesth Plast Surg. CrossRefGoogle Scholar
  2. 2.
    Clemens MW, Medeiros LJ, Butler CE et al (2016) Complete surgical excision is essential for the management of patients with breast implant-associated anaplastic large-cell lymphoma. J Clin Oncol 34(2):160–168CrossRefPubMedGoogle Scholar
  3. 3.
    Clemens MW, Horwitz SM (2017) NCCN consensus guidelines for the diagnosis and management of breast implant-associated anaplastic large cell lymphoma. Aesthet Surg J 37:285–289CrossRefPubMedGoogle Scholar
  4. 4.
    Clemens MW, Brody GS, Mahabir RC, Miranda RN (2018) How to diagnose and treat breast implant-associated anaplastic large cell lymphoma. Plast Reconstr Surg 141(4):586e–599eCrossRefPubMedGoogle Scholar
  5. 5.
    Kalialis LV, Drzewiecki KT, Klyver H (2009) Spontaneous regression of metastases from melanoma: review of the literature. Melanoma Res 19(5):275–282CrossRefPubMedGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery 2018

Authors and Affiliations

  1. 1.Department of HematopathologyM.D. Anderson Cancer CenterHoustonUSA
  2. 2.Department of Plastic SurgeryM.D. Anderson Cancer CenterHoustonUSA

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