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Desmoid Tumor and Silicone Breast Implant Surgery: Is There Really a Connection? A Literature Review

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  • Breast Surgery
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Abstract

Background

Desmoid tumors are borderline tumors of the connective tissue, arising in the musculo-aponeurotic stromal elements. A desmoid tumor (DT) has an infiltrative and locally aggressive growth pattern and usually does not metastasize; however, it has a high recurrence and complication rate. DT located in the breast (BDT) represents a rare extra-abdominal form. Recently, the presence of breast silicone implants was suggested by several researchers as a risk factor for developing BDT.

Objectives

The goal of this review is to investigate the possible correlation between BDT and breast implant surgery.

Methods

We conducted a literature review of BDT-reported cases, associated with breast implant surgery.

Results

The search revealed 36 cases of BDT associated with silicone breast implants.

Conclusions

Based on the reviewed data, the incidence of BDT following breast implant surgery is lower than BDT in the general population. At the moment, a possible association between breast implants and the development of breast desmoid tumors cannot be unequivocally confirmed. A world registry with accurate documentation of each case of BDT associated with breast implant surgery should be performed for future investigation.

Level of Evidence II

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References

  1. Sakorafas GH, Nissotakis C, Peros G (2007) Abdominal desmoid tumors. Surg Oncol 16:131–142

    Article  PubMed  Google Scholar 

  2. Chummun S, Mclean NR, Abraham S, Youseff M (2010) Desmoid tumour of the breast. J Plast Reconstr Aesthet Sur 63:339–345

    Article  Google Scholar 

  3. Balzer BL, Weiss SW (2009) Do biomaterials cause implant-associated mesenchymal tumors of the breast? Analysis of 8 new cases and review of the literature. Hum Pathol 40:1564–1570

    Article  CAS  PubMed  Google Scholar 

  4. Jandali AR, Wedler V, Meuli-Simmen C, Künzi W, Meyer VE (2004) Mammaimplantat und Desmoidtumoren: besteht ein Zusammenhang? Handchir Mikrochir Plast Chir 36(6):343–347

    Article  CAS  PubMed  Google Scholar 

  5. Cohen S, Ad-El D, Benjaminov O, Gutman H (2008) Post-traumatic soft tissue tumors: case report and review of the literature a propos a Post-traumatic paraspinal desmoid tumor. World J Surg Oncol 6(1):28

    Article  PubMed  PubMed Central  Google Scholar 

  6. Rosen PP, Ernsberger D (1989) Mammary fibromatosis. A benign spindle-cell tumor with significant risk for local recurrence. Cancer 63(7):1363–1369

    Article  CAS  PubMed  Google Scholar 

  7. Ackman JB, Whitman GJ, Chew FS (1994) Aggressive fibromatosis. Am J Roentgenol 163(3):544

    Article  CAS  Google Scholar 

  8. Schlemmer M (2005) Desmoid tumors and deep fibromatoses. Hematol Oncol Clin North Am 19(3):565–571

    Article  PubMed  Google Scholar 

  9. Taylor TV, Sosa J (2011) Bilateral breast fibromatosis: case report and review of the literature. J Surg Educ 68(4):320–325

    Article  PubMed  Google Scholar 

  10. Shields C, Winter D, Kirwan W, Redmond H (2001) Desmoid tumours. Eur J Surg Oncol 27(8):701–706

    Article  CAS  PubMed  Google Scholar 

  11. Neuman HB, Brogi E, Ebrahim A, Brennan MF, Zee KJV (2007) Desmoid tumors (fibromatoses) of the breast: a 25-year experience. Ann Surg Oncol 15(1):274–280

    Article  PubMed  Google Scholar 

  12. Erguvan-Dogan B, Dempsey PJ, Ayyar G, Gilcrease MZ (2005) Primary desmoid tumor (extraabdominal fibromatosis) of the breast. Am J Roentgenol 185(2):488–489

    Article  Google Scholar 

  13. Jewett ST, Mead JH (1979) Extra-abdominal desmoid arising from a capsule around a silicone breast implant. Plast Reconstr Surg 63(4):577–579

    Article  PubMed  Google Scholar 

  14. Schuh ME, Radford DM (1994) Desmoid tumor of the breast following augmentation mammaplasty. Plast Reconstr Surg 93(3):603–605

    Article  CAS  PubMed  Google Scholar 

  15. Gergelé F, Guy F, Collin F, Krausé D (2012) A desmoid tumour associated with a breast prosthesis. Diagn Interv Imaging 93(3):200–203

    Article  Google Scholar 

  16. Herborn CU, Marincek B, Erfmann D, Meuli-Simmen C, Wedler V, Bode-Lesniewska B, Kubik-Huch RA (2002) Breast augmentation and reconstructive surgery: MR imaging of implant rupture and malignancy. Eur Radiol 12(9):2198–2206

    Article  PubMed  Google Scholar 

  17. Seo YN, Park YM, Yoon HK, Lee SJ, Choo HJ, Ryu JH (2015) Breast fibromatosis associated with breast implants. Jpn J Radiol 33(9):591–597

    Article  PubMed  Google Scholar 

  18. Mátrai ZCA, Tóth L, Gulyás G, Szabó É, Szentirmay Z, Kásler M (2011) A desmoid tumor associated with a ruptured silicone breast implant. Plast Reconstr Surg 127(1):1e–4e

    Article  PubMed  Google Scholar 

  19. Henderson PW, Singh SP, Spector JA (2010) Chest wall spindle cell fibromatosis after breast augmentation. Plast Reconstr Surg 126(2):94e–95e

    Article  PubMed  Google Scholar 

  20. Hammoudeh ZS, Darian VB (2012) Desmoid tumor (fibromatosis) of the breast after augmentation with saline implants. Plast Reconstr Surg 129:753e–754e

    Article  CAS  PubMed  Google Scholar 

  21. Jeong WS, Oh TS, Sim HB, Eom JS (2013) Desmoid tumor following augmentation mammoplasty with silicone implants. Arch Plast Surg 40(4):470

    Article  PubMed  PubMed Central  Google Scholar 

  22. Vandeweyer E, Deraemaecker R (2000) Desmoid tumor of the breast after reconstruction with implant. Plast Reconstr Surg 105(7):2627

    Article  CAS  PubMed  Google Scholar 

  23. Shim HS, Kim S-J, Kim OH, Jung HK, Kim SJ, Kim W, Kim WW (2014) Fibromatosis associated with silicone breast implant: ultrasonography and MR imaging findings. Breast J 20(6):645–649

    Article  PubMed  Google Scholar 

  24. Khanfir K (2003) Unusual problems in breast cancer and a rare lung cancer case: case 2. Aggressive fibromatosis of the chest wall arising near a breast prosthesis. J Clin Oncol 21(11):2216–2218

    Article  PubMed  Google Scholar 

  25. Schiller VL, Arndt RD, Brenner RJ (1995) Aggressive fibromatosis of the chest associated with a silicone breast implant. Chest 108(5):1466–1468

    Article  CAS  PubMed  Google Scholar 

  26. Aaron A, O’Mara J, Legendre K, Evans S, Attinger C, Montgomery E (1996) Chest wall fibromatosis associated with silicone breast implants. Surg Oncol 5(2):93–99

    Article  CAS  PubMed  Google Scholar 

  27. Dale PS, Wardlaw JC, Wootton DG, Resnick JI, Giuliano AE (1995) Desmoid tumor occurring after reconstruction mammaplasty for breast carcinoma. Ann Plast Surg 35(5):515–518

    Article  CAS  PubMed  Google Scholar 

  28. Kim MJJ, Wapnir IL, Ikeda DM, Chisholm KM, Do Y, Daniel BL (2012) MRI enhancement correlates with high grade desmoid tumor of breast. Breast J 18(4):374–376

    Article  PubMed  Google Scholar 

  29. Crestinu JM (1995) Dismoid tumor of the breast. Plast Reconstr Surg 95(2):421

    Article  CAS  PubMed  Google Scholar 

  30. Abraham SC, Reynolds C, Lee J-H, Montgomery EA, Baisden BL, Krasinskas AM, Wu T (2002) Fibromatosis of the breast and mutations involving the APC/β-catenin pathway. Hum Pathol 33(1):39–46

    Article  CAS  PubMed  Google Scholar 

  31. Mazzocchi M, Onesti MG, Di Ronza S, Scuderi N (2009) Breast desmoid tumor after augmentation mammoplasty: two case reports. Acta Chir Plast 51:73–78

    CAS  PubMed  Google Scholar 

  32. Gandolfo L, Guglielmino S, Lorenzetti P, Fiducia G, Scenna G, Bosco V (2006) Chest wall fibromatosis after mammary prosthesis implantation. A case report and review of the literature. Chir Ital 58:655–660

    PubMed  Google Scholar 

  33. Jamshed S, Farhan MI, Marshall MB, Nahabedian MY, Liu MC (2008) Fibromatosis of the breast after mammary prosthesis implantation. Clin Adv Hematol Oncol 6:687–694

    PubMed  Google Scholar 

  34. Keech JA, Creech BJ (1997) Anaplastic T-cell lymphoma In proximity to a saline-filled breast implant. Plast Reconstr Surg 100(2):554–555

    Article  PubMed  Google Scholar 

  35. Brody GS (2015) Anaplastic large cell lymphoma occurring in women with breast implants: analysis of 173 cases. Plast Reconstr Surg 136(4):553e–554e

    Article  CAS  PubMed  Google Scholar 

  36. Reports of Anaplastic Large Cell Lymphoma (ALCL) in women with breast implants: FDA safety communication.”Reports of Anaplastic Large Cell Lymphoma (ALCL) in Women with Breast Implants: FDA Safety Communication. N.p., 26 Jan. 2011. http://www.fda.gov/

  37. Urist MR (1957) Trauma and neoplasm: report of a case of desmoid tumor following simple fracture of the radius and ulna. Am J Surg 93:682–688

    Article  CAS  PubMed  Google Scholar 

  38. Enzinger FM, Shiraki M (1967) Musculo-aponeurotic fibromatosis of the shoulder girdle (extra-abdominal desmoid): analysis of thirty cases followed up for ten or more years. Cancer 20:1131–1140

    Article  CAS  PubMed  Google Scholar 

  39. Bertario L, Russo A, Sala P, Eboli M, Giarola M, D’amico F, Gismondi V, Varesco L, Pierotti MA, Radice P (2001) Genotype and phenotype factors as determinants of desmoid tumors in patients with familial adenomatous polyposis. Int J Cancer 95:102–107

    Article  CAS  PubMed  Google Scholar 

  40. Lacayo EA, Glastonbury CM, Hoang JK, Magliocca KR, Hill KL, Hudgins PA (2016) Deep neck fibromatosis after diskectomy and cervical fusion: case series and review of the literature. Am J Roentgenol 206(5):1068–1072

    Article  Google Scholar 

  41. Mori T, Yamada T, Ohba Y, Yoshimoto K, Ikeda K, Shiraishi K, Suzuki M (2014) A case of desmoid-type fibromatosis arising after thoracotomy for lung cancer with a review of the English and Japanese literature. Ann Thorac Cardiovasc Surg 20(Supplement):465–469

    Article  PubMed  Google Scholar 

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Authors and Affiliations

  1. Plastic and Reconstructive Surgery Department, Soroka University Medical Center, Ben Gurion University of Negev, Beersheba, Israel

    R. Tzur, E. Silberstein, Y. Krieger, Y. Shoham & A. Bogdanov-Berezovsky

  2. Cardio- Thoracic Surgery Department, Soroka University Medical Center, Ben Gurion University of Negev, Beersheba, Israel

    Y. Rafaeli

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  1. R. Tzur
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  2. E. Silberstein
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  3. Y. Krieger
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  6. A. Bogdanov-Berezovsky
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Correspondence to A. Bogdanov-Berezovsky.

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Tzur, R., Silberstein, E., Krieger, Y. et al. Desmoid Tumor and Silicone Breast Implant Surgery: Is There Really a Connection? A Literature Review. Aesth Plast Surg 42, 59–63 (2018). https://doi.org/10.1007/s00266-017-0948-2

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  • DOI: https://doi.org/10.1007/s00266-017-0948-2

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