International Orthopaedics

, Volume 42, Issue 7, pp 1551–1556 | Cite as

Combined pharmacotherapy for osteonecrosis of the femoral head after severe acute respiratory syndrome and interstitial pneumonia: two and a half to fourteen year follow-up

  • Weiguo Wang
  • Nianfei Zhang
  • Wanshou Guo
  • Fuqiang Gao
Original Paper



The purpose of this study was to retrospectively analyze the clinical, functional, and radiological outcomes of combined pharmacotherapy to ONFH after high-dose corticosteroid therapy.


From August 2003 to June 2015, five patients (ten hips) of ONFH in ARCO stage I, after SARS and Interstitial pneumonia, were treated by combined pharmacotherapy. Lipo-prostaglandin E1 10 μg iv Bid × 28 days, enoxaparin 6000 iu H QD × 12 weeks, alendronate sodium tablet 10 mg QD × 1 year. The patients were fully weight-bearing following completion of the follow-up.


For these five patients (ten hips), Harris score was 100 from the diagnosis to final follow-up time. Radiologic findings show no signs of collapse, necrotic focus was repaired, and ARCO stages were changed from IC into IIB.


This combined pharmacotherapy has promising treatment results for delaying or preventing collapse of ONFH in ARCO stage I.


Osteonecrosis of the femoral head Porous media Subchondral plate Collapse Pharmacotherapy 


Compliance with ethical standards

This study was approved by the Institutional Review Board on Human Studies of the Ethical Committee of China-Japan Friendship hospital, and informed consent was obtained from all the patients.

Conflict of interest

We did not receive any benefits directly or indirectly from commercial parties.


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Copyright information

© SICOT aisbl 2018

Authors and Affiliations

  1. 1.Department of Orthopaedic SurgeryChina-Japan Friendship HospitalBeijingPeople’s Republic of China

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