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Etidronate does not suppress periprosthetic bone loss following cemented hip arthroplasty

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Abstract

Periprosthetic bone loss after arthroplasty may threaten prosthesis survival. The current study investigated the effect of etidronate therapy on periprosthetic, contralateral hip, and spine bone mineral density (BMD) in a one-year, prospective, randomized, double-blind study on 46 patients after cemented hip arthroplasty. BMD was measured with dual-energy X-ray absorptiometry (DXA). There were no significant differences between mean BMD measurements of the etidronate and placebo groups, with the exception of the mean percent change in the spine at six months and 12 months and in Gruen zone 3 at six months; in all three cases, the etidronate group had significantly greater mean values. These findings suggest that cyclic etidronate therapy has no significant effect in suppressing periprosthetic bone loss following cemented hip arthroplasty.

Résumé

La perte osseuse périprothétique après arthroplastie peut mettre en danger la survie de la prothèse. Nous avons étudié l'effet de l'étidronate sur la densité minérale (DM) de l'os en zone périprothétique, au niveau de la hanche opposée et du rachis. L'étude à un an, prospective, randomisée et en double-aveugle a inclue 46 malades après arthroplastie de la hanche cimentée. La DM était mesurée par absorptiométrie biphotonique (DXA). En général, il n'y avait pas de différence significative entre la DM moyenne du groupe étidronate et du groupe placebo. Les seules exceptions étaient les changements en pourcentage sur le rachis après 6 et 12 mois et en Zone 3 de Gruen après 6 mois; dans tous ces cas, le groupe étidronate avait des valeurs moyennes significativement plus grandes. Ces résultats indiquent que la thérapie cyclique par étidronate n'a pas d'effet significatif pour enrayer la perte osseuse périprothétique après arthroplastie cimentée de la hanche.

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Acknowledgements

The authors thank Mrs. Mateja Znidar, Barbara Klancnik-Pirs, and Bojana Jecl for their expert technical assistance and Mrs. Sandra Turk for her expert statistical assistance during the course of this study. They acknowledge Krka for providing free drugs for the sole purpose of this trial.

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Authors and Affiliations

  1. Department of Orthopaedic Surgery and Sports Trauma, Celje General Hospital, Oblakova 5, 3000, Celje, Slovenia

    S. K. Fokter

  2. Department of Trauma, Celje General Hospital, Celje, Slovenia

    R. Komadina

  3. Department for Pathology and Cytopathology, Celje General Hospital, Celje, Slovenia

    A. Repše-Fokter

  4. San Francisco Orthopaedic Residency Program, San Francisco, CA, USA

    S. A. Yerby

  5. VA Rehab R&D Center, Palo Alto, CA, USA

    S. A. Yerby

  6. St. Francis Medical Technologies, Alameda, CA, USA

    S. A. Yerby

  7. Department of Endocrinology and Metabolic Diseases, Clinical Centre, Ljubljana, Slovenia

    A. Kocijančič

  8. Faculty of Pharmacy, University of Ljubljana, Ljubljana, Slovenia

    J. Marc

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  1. S. K. Fokter
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  2. R. Komadina
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  3. A. Repše-Fokter
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  4. S. A. Yerby
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  6. J. Marc
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Correspondence to S. K. Fokter.

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Fokter, S.K., Komadina, R., Repše-Fokter, A. et al. Etidronate does not suppress periprosthetic bone loss following cemented hip arthroplasty. International Orthopaedics (SICO 29, 362–367 (2005). https://doi.org/10.1007/s00264-005-0018-2

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  • DOI: https://doi.org/10.1007/s00264-005-0018-2

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