Abstract
We compared type I collagen degradation using serum cross-linking C-terminal telopeptide (ICTP) in 18 patients with rapidly destructive osteoarthrosis and in 20 patients with slowly progressive osteoarthrosis of the hip. The diagnosis was established by clinical examination and radiographic evaluation. Total hip arthroplasty was performed in all patients. Serum levels of ICTP, bone-specific alkaline phosphatase, osteocalcin and N-terminal propeptide were studied. Patients with rapidly destructive osteoarthrosis had higher mean (SD) serum ICTP levels than patients with slowly progressive osteoarthrosis [13.2 (5.6) versus 3.7 ng/ml (1.4), p=0.001] whereas no significant difference of all other markers was seen between the groups. Elevation of ICTP levels correlated significantly with decreased joint-space width assessed by radiographs of the hip (p=0.01). Our data suggest that rapidly destructive hip osteoarthrosis is associated with elevated serum ICTP levels, reflecting increased collagen type I degradation.
Résumé
Nous avons comparé la dégradation du collagène type I en utilisant le cross-linking du telopeptide Terminal C (ICTP) chez 18 malades avearthrose rapidement destructrice et chez 20 malades avecarthrose lentement progressive de la hanche. Le diagnostic a été établi par examen clinique et évaluation radiographique. L’arthroplastie totale de la hanche a été exécuté chez tous les malades. Le niveau sérique d’ICTP, des phosphatases alcalines osseuse spécifiques, de l’ostéocalcine, et du propeptide N-Terminal a été étudié. Les malades avec arthrose rapidement destructrice avaient une moyenne du niveau d’ICTP nettement plus haute que les malades avec arthrose lentement progressive [13.2 (5.6) vs 3.7 ng/ml (1.4), p=0.001], alors qu’aucune différence notable de tous les autres marqueurs n’a été notée entre les groupes. L’élévation de niveau de l› ICTP était en corrélation avec la hauteur de l’interligne articulaire apprécié par des radiographies (p=0.01). Nos données suggèrent que l’arthrose rapidement destructive est associé à une élévation sérique de l’ICTP reflétant une augmentation de la dégradation du collagène de type I.
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Berger, C.E., Kröner, A., Stiegler, H. et al. Elevated levels of serum type I collagen C-telopeptide in patients with rapidly destructive osteoarthritis of the hip. International Orthopaedics (SICOT) 29, 1–5 (2005). https://doi.org/10.1007/s00264-004-0608-4
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DOI: https://doi.org/10.1007/s00264-004-0608-4