Advertisement

Cancer Immunology, Immunotherapy

, Volume 63, Issue 3, pp 305–311 | Cite as

“Tumor Immunology Meets Oncology (TIMO) IX”, May 2–4, 2013, Halle/Saale, Germany

  • Barbara SeligerEmail author
Meeting Report
  • 248 Downloads

The immune system plays an important role in cancer since it could repress tumor growth, but could also enhance tumorigenicity. This led during the last years to a renaissance in cancer immunotherapy with an increased number of preclinical and clinical studies. Different new (immuno) therapeutic strategies have been recently explored, which are able to specifically target tumor cells or improve immune responses. These include, e.g., the augmentation of professional antigen-presenting cells (APCs) and immune effector cells, immunologic stimulants, adoptive transfer of transgenic immune cells, antibodies inhibiting negative signals and DNA-, RNA- and peptide-based vaccines. However, despite an increased efficacy of these treatment modalities, a long-term benefit for patients have not yet been observed, which might be due to the evasion of tumor cells from immune surveillance. Indeed, tumors developed strategies to escape immune responses, which could occur at three distinct levels: (1)...

Keywords

TIMO Meeting report Tumor immunology Immune escape Immunotherapy 

Abbreviations

ACT

Adoptive T cell therapy

ALC

Absolute lymphocyte count

APC

Antigen-presenting cell

APM

Antigen processing machinery

bgn

Biglycan

CAR

Chimeric antigen receptor

CIC

Cancer-initiating cell

CRC

Colorectal carcinoma

CREB

cAMP response element-binding protein

CTL

Cytotoxic T lymphocytes

DAC

5-Aza-2’-deoxycytidine

DC

Dendritic cell

HC

Heavy chain

IFN

Interferon

ILT

Immunoglobulin-like transcript

KIR

Killer cell immunoglobulin-like receptor

LDH

Lactate dehydrogenase

mAb

Monoclonal antibody

MDSC

Myeloid-derived suppressor cells

MEK

Mitogen-activated protein kinase

miR

microRNA

NK

Natural killer

NKR-L

NK cell receptor ligand

OS

Overall survival

PBC

Peripheral blood cells

PBL

Peripheral blood lymphocyte

PBMC

Peripheral blood mononuclear cells

PC

Prostate cancer

PI3K

Phosphatidylinositol 3-kinase

PTM

Post-translational modifications

RCC

Renal cell carcinoma

SCNP

Single cell network profiling

SNP

Single nucleotide polymorphism

TAP

Transporter associated with antigen processing

TCR

T cell receptor

TIL

Tumor-infiltrating lymphocyte

TLR

Toll-like receptor

Treg

Regulatory T cell

UTR

Untranslated region

Notes

Conflict of interest

The author declares that she has no conflict of interest, but act as co-organizer of this meeting.

Copyright information

© Springer-Verlag Berlin Heidelberg 2014

Authors and Affiliations

  1. 1.Institute of Medical ImmunologyMartin-Luther University Halle-WittenbergHalleGermany

Personalised recommendations