Role of CT in the prediction of pathological complete response in gastric cancer after neoadjuvant chemotherapy



To explore which computed tomography (CT) features can predict pathological complete response (pCR) (ypT0N0) after neoadjuvant chemotherapy (NAC) in patients with gastric adenocarcinoma (GC).

Materials and Methods

This study reviewed an institutional database of patients who underwent resection of GC after NAC and identified patients with pCR from January 2010 to December 2013. The correlations between pre-chemotherapy and post-chemotherapy CT features and pCR were analyzed.


Eleven of 199 patients with GC who achieved ypT0N0 status after NAC were classified as the pCR group in this study. After matching pCR (n = 11) and non-pCR patients (n = 44) in the ratio of 1:4, a total of 55 cases were analyzed. The binary logistic regression analysis showed that the post-chemotherapy short diameter of the largest lymph node and tumor thickness ratio reduction were independent predictors of pCR, with an area under the curve (AUC) of 0.94 on the receiver operating characteristic (ROC) curve analysis.


Two CT features, including the short diameter of the largest lymph node post-chemotherapy and tumor thickness ratio reduction, are good predictors of pCR after NAC in patients with GC.

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Computed tomography


Pathological complete response


Neoadjuvant chemotherapy


Receiver operating characteristic curve


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This work was supported by the Digestive Medical Coordinated Development Center of Beijing Municipal Administration of Hospitals (No. XXT20), Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support(No. ZYLX201803), and Beijing Hospitals Authority’ Ascent Plan (Code: 20191103).

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Correspondence to Ying-Shi Sun.

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Wang, ZL., Li, YL., Li, XT. et al. Role of CT in the prediction of pathological complete response in gastric cancer after neoadjuvant chemotherapy. Abdom Radiol (2021).

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  • Gastric cancer
  • Computed tomography
  • Pathological complete response
  • Neoadjuvant chemotherapy