Evaluation of clinical and imaging biomarkers for the prediction of new onset diabetes following pancreatic resection

Abstract

Purpose

To identify clinical and imaging biomarkers that can predict the new onset of diabetes mellitus (NODM) within 1 year of pancreatic resection.

Methods

A retrospective chart review was conducted of 426 non-diabetic patients who underwent a pancreaticoduodenectomy or distal pancreatectomy at the University of Pittsburgh Medical Center between 2006 and 2016. Clinical characteristics and the patient’s diabetic status at 1-year post resection were collected from the EMR. Imaging biomarkers included hepatic and pancreatic fat replacement, pancreatic calcifications, pancreatic duct diameter, pancreatic volume and body composition. Univariate and multivariable analyses were performed to demonstrate any predictive biomarkers of diabetes occurrence within 1 year of pancreatic resection.

Results

135/426 (31.7%) patients developed NODM. The only significant clinical predictor was older age (OR 1.02, 95% CI 1.002–1.039, p = 0.032). Imaging characteristics found to be significant included hepatic steatosis (OR 1.777, 95% CI 1.094–2.886, p = 0.02), larger reduction in pancreas volume (OR 0.989, 95% CI 0.979–0.999, p = 0.027), and greater preoperative visceral fat (OR 1.004, 95% CI 1.001–1.006, p = 0.001).

Conclusion

Age, presence of hepatic steatosis, change in pancreatic volume, and preoperative visceral fat are independent predictive biomarkers for NODM following pancreatic resection.

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Acknowledgements

The statistical analysis for this project was supported in part by the National Institutes of Health through Grant Number UL1-TR-001857.

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Correspondence to Alessandro Furlan.

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Donovan, A.L., Furlan, A., Borhani, A.A. et al. Evaluation of clinical and imaging biomarkers for the prediction of new onset diabetes following pancreatic resection. Abdom Radiol (2021). https://doi.org/10.1007/s00261-020-02943-3

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Keywords

  • Diabetes
  • Computed tomography
  • Pancreatic resection
  • Hepatic steatosis