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Robotic-assisted transrectal MRI-guided biopsy. Technical feasibility and role in the current diagnosis of prostate cancer: an initial single-center experience

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Abstract

Objectives

To evaluate the potential clinical and technical utility to manage in practice the use of a robotic MRI in-bore-targeted prostate biopsies in the current work-up of prostate cancer diagnosis.

Methods

Thirty patients with a single cancer suspicious lesion interpreted on MRI using PI-RADSv2.1 category ≥ 3 underwent in-bore robotic transrectal MRI remote-controlled-guided biopsy. It was analyzed the technical success, clinical details, biopsy findings in correlation with the MRI examination, complications and cancer detection rate (CDR).

Results

The overall CDR for any cancer was 73% (22/30). It was 86% (19/22) for significant tumors (Gleason score of more than 6 or maximum cancer core length greater than 3 mm for Gleason 6) and 77% (17/22) for tumors with Gleason > 6. CDR for biopsy-naïve patients was 89% (16/18) and 50% (6/12) for patients with prior negative transrectal ultrasound-guided biopsies. The CDR for PI-RADS > 3 was 92% (22/24). All the lesions (n = 30) were reachable with the robotic MRI device. A self-limited rectal hemorrhagic complication was reported.

Conclusion

This initial data show that a robotic MRI-guided biopsy could be useful, efficient and feasible procedure in the new paradigm to diagnose significant prostate cancer in selected patients.

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Funding

The authors state that this work has not received any funding.

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Authors and Affiliations

  1. Department of Magnetic Resonance, Clinica Girona, 17002, Girona, Spain

    Joan C. Vilanova, Anna Pérez de Tudela, Joaquim Barceló, Montse Planas & Sònia Sala

  2. Research Unit of Diagnostic Imaging Institute (IDI), Department of Radiology, Girona Biomedical Research Institute, IDIBGI, Hospital Universitari Dr. Josep Trueta, 17007, Girona, Spain

    Joan C. Vilanova, Josep Puig & Joaquim Barceló

  3. Department of Medical Sciences, Faculty of Medicine, University of Girona, 17003, Girona, Spain

    Joan C. Vilanova & Joaquim Barceló

  4. Soteria Medical, Arnhem, The Netherlands

    Martijn Hoogenboom

  5. Department of Computer Science, Applied Mathematics and Statistics, University of Girona, 17003, Girona, Spain

    Santiago Thió-Henestrosa

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  1. Joan C. Vilanova
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Contributions

All authors whose names appear on the submission made substantial contributions to the conception or design of the work; or the acquisition, analysis, or interpretation of data; or the creation of new software used in the work. Approved the version to be published; and agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

Corresponding author

Correspondence to Joan C. Vilanova.

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Guarantor

The scientific guarantor of this publication is Joan C Vilanova.

Conflict of interest

The authors of this manuscript declare relationships with the following companies: Soteria Medical: Martijn Hoogenboom. The authors: Joan C. Vilanova, Anna Pérez de Tudela, Josep Puig, Joaquim Barceló, Montse Planas, Sònia Sala, Santiago Thio-Henestrosa of this manuscript declare no relationships with any companies, whose products or services may be related to the subject matter of the article.

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Written informed consent was obtained from all subjects (patients) in this study.

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Vilanova, J.C., Pérez de Tudela, A., Puig, J. et al. Robotic-assisted transrectal MRI-guided biopsy. Technical feasibility and role in the current diagnosis of prostate cancer: an initial single-center experience. Abdom Radiol 45, 4150–4159 (2020). https://doi.org/10.1007/s00261-020-02665-6

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