To review the current body of evidence surrounding non-imaging biomarkers in patients with known or suspected prostate cancer.
Several non-imaging biomarkers have been developed and are available that aim to improve risk estimates at several clinical junctures. For patients with suspicion of prostate cancer who are considering first-time or repeat biopsy, blood- and urine-based assays can improve the prediction of harboring clinically significant disease and may reduce unnecessary biopsy. Blood- and urine-based biomarkers have been evaluated in association with prostate MRI, offering insights that might augment decision-making in the pre and post-MRI setting. Tissue-based genomic and proteomic assays have also been developed that provide independent assessments of prostate cancer aggressiveness that can complement imaging.
A growing number of non-imaging biomarkers are available to assist in clinical decision-making for men with known or suspected prostate cancer. An appreciation for the intersection of imaging and biomarkers may improve clinical care and resource utilization for men with prostate cancer.
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Rajwa, P., Syed, J. & Leapman, M.S. How should radiologists incorporate non-imaging prostate cancer biomarkers into daily practice?. Abdom Radiol 45, 4031–4039 (2020). https://doi.org/10.1007/s00261-020-02496-5
- Prostate cancer
- Molecular markers
- Prostate biopsy non-imaging biomarkers