Skip to main content
Log in

Acute pancreatitis: an update on the revised Atlanta classification

  • Special Section: Pancreatitis
  • Published:
Abdominal Radiology Aims and scope Submit manuscript

Abstract

Acute pancreatitis (AP) is the most common gastrointestinal disease resulting in hospitalization in the United States with reports of over 270,000 hospitalizations and costs up to 2.6 billion dollars per year. AP is highly variable in disease course and outcome. Established in 1992, the original Atlanta classification system aimed to categorize the wide spectrum of AP by creating consensus-based terminology for AP types, severity, and complications. Though the original system standardized terminology, certain terms and definitions (i.e. pancreatic abscess) were unclear and often misused. The 2012 revised Atlanta classification (RAC) system updated terms, clarified definitions, and incorporated the medical community’s improved understanding of the physiology of AP. The resulting RAC effectively defined the morphologic types of pancreatitis, provided a more standardized system for disease severity grading, further classified the local retroperitoneal complications, and established objective measures to describe this highly variable but common disease. This review provides an update on the recent literature evaluating the RAC, discusses both the strengths and shortcomings of the RAC system (including problematic interobserver agreement), and considers improvements for future classification systems.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Fig. 1
Fig. 2
Fig. 3
Fig. 4
Fig. 5
Fig. 6
Fig. 7

Similar content being viewed by others

References

  1. Peery AF, Dellon ES, Lund J, Crockett SD, McGowan CE, Bulsiewicz WJ, Gangarosa LM, Thiny MT, Stizenberg K, Morgan DR, Ringel Y, Kim HP, DiBonaventura MD, Carroll CF, Allen JK, Cook SF, Sandler RS, Kappelman MD, Shaheen NJ (2012) Burden of gastrointestinal disease in the United States: 2012 update. Gastroenterology 143 (5):1179-1187 e1173. https://doi.org/10.1053/j.gastro.2012.08.002

    Article  PubMed  PubMed Central  Google Scholar 

  2. Yadav D, Lowenfels AB (2013) The epidemiology of pancreatitis and pancreatic cancer. Gastroenterology 144 (6):1252-1261. https://doi.org/10.1053/j.gastro.2013.01.068

    Article  PubMed  PubMed Central  Google Scholar 

  3. Forsmark CE, Baillie J, Practice AGAIC, Economics C, Board AGAIG (2007) AGA Institute technical review on acute pancreatitis. Gastroenterology 132 (5):2022-2044. https://doi.org/10.1053/j.gastro.2007.03.065

    Article  CAS  PubMed  Google Scholar 

  4. Bradley E (1993) A clinically based classification system for acute pancreatitis. Summary of the International Symposium on Acute Pancreatitis, Atlanta, Ga, September 11 through 13, 1992. Archives of Surgery 128 (5):586-590

  5. Shinagare AB, Ip IK, Raja AS, Sahni VA, Banks P, Khorasani R (2015) Use of CT and MRI in emergency department patients with acute pancreatitis. Abdom Imaging 40 (2):272-277. https://doi.org/10.1007/s00261-014-0210-1

    Article  PubMed  Google Scholar 

  6. Dachs RJ, Sullivan L, Shanmugathasan P (2015) Does early ED CT scanning of afebrile patients with first episodes of acute pancreatitis ever change management? Emerg Radiol 22 (3):239-243. https://doi.org/10.1007/s10140-014-1266-5

  7. Foster BR, Jensen KK, Bakis G, Shaaban AM, Coakley FV (2016) Revised Atlanta Classification for Acute Pancreatitis: A Pictorial Essay. Radiographics 36 (3):675-687. https://doi.org/10.1148/rg.2016150097

    Article  PubMed  Google Scholar 

  8. Banks PA, Bollen TL, Dervenis C, Gooszen HG, Johnson CD, Sarr MG, Tsiotos GG, Vege SS, Group APCW (2013) Classification of acute pancreatitis–2012: revision of the Atlanta classification and definitions by international consensus. Gut 62 (1):102-111. https://doi.org/10.1136/gutjnl-2012-302779

    Article  PubMed  Google Scholar 

  9. Banks PA, Freeman ML, Practice Parameters Committee of the American College of G (2006) Practice guidelines in acute pancreatitis. Am J Gastroenterol 101 (10):2379-2400. https://doi.org/10.1111/j.1572-0241.2006.00856.x

    Article  PubMed  Google Scholar 

  10. Turkvatan A, Erden A, Turkoglu MA, Secil M, Yener O (2015) Imaging of acute pancreatitis and its complications. Part 1: acute pancreatitis. Diagn Interv Imaging 96 (2):151-160. https://doi.org/10.1016/j.diii.2013.12.017

    Article  CAS  PubMed  Google Scholar 

  11. Brown LA, Hore TA, Phillips AR, Windsor JA, Petrov MS (2014) A systematic review of the extra-pancreatic infectious complications in acute pancreatitis. Pancreatology 14 (6):436-443. https://doi.org/10.1016/j.pan.2014.09.010

    Article  PubMed  Google Scholar 

  12. Johnson CD, Abu-Hilal M (2004) Persistent organ failure during the first week as a marker of fatal outcome in acute pancreatitis. Gut 53 (9):1340-1344. https://doi.org/10.1136/gut.2004.039883

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Marshall JC, Cook DJ, Christou NV, Bernard GR, Sprung CL, Sibbald WJ (1995) Multiple organ dysfunction score: a reliable descriptor of a complex clinical outcome. Crit Care Med 23 (10):1638-1652

    Article  CAS  Google Scholar 

  14. Petrov MS, Shanbhag S, Chakraborty M, Phillips AR, Windsor JA (2010) Organ failure and infection of pancreatic necrosis as determinants of mortality in patients with acute pancreatitis. Gastroenterology 139 (3):813-820. https://doi.org/10.1053/j.gastro.2010.06.010

    Article  PubMed  Google Scholar 

  15. Quinlan JD (2014) Acute pancreatitis. Am Fam Physician 90 (9):632-639

    PubMed  Google Scholar 

  16. Reynolds PT, Brady EK, Chawla S (2018) The utility of early cross-sectional imaging to evaluate suspected acute mild pancreatitis. Ann Gastroenterol 31 (5):628-632. https://doi.org/10.20524/aog.2018.0291

    Article  PubMed  PubMed Central  Google Scholar 

  17. Padhan RK, Jain S, Agarwal S, Harikrishnan S, Vadiraja P, Behera S, Jain SK, Dhingra R, Dash NR, Sahni P, Garg PK (2018) Primary and Secondary Organ Failures Cause Mortality Differentially in Acute Pancreatitis and Should be Distinguished. Pancreas 47 (3):302-307. https://doi.org/10.1097/mpa.0000000000000998

    Article  PubMed  Google Scholar 

  18. Singh VK, Bollen TL, Wu BU, Repas K, Maurer R, Yu S, Mortele KJ, Conwell DL, Banks PA (2011) An assessment of the severity of interstitial pancreatitis. Clin Gastroenterol Hepatol 9 (12):1098-1103. https://doi.org/10.1016/j.cgh.2011.08.026

    Article  PubMed  Google Scholar 

  19. Karakayali FY (2014) Surgical and interventional management of complications caused by acute pancreatitis. World J Gastroenterol 20 (37):13412-13423. https://doi.org/10.3748/wjg.v20.i37.13412

    Article  PubMed  PubMed Central  Google Scholar 

  20. Besselink MG, van Santvoort HC, Bollen TL, van Leeuwen MS, Lameris JS, van der Jagt EJ, Strijk SP, Buskens E, Freeny PC, Gooszen HG, Dutch Acute Pancreatitis Study G (2006) Describing computed tomography findings in acute necrotizing pancreatitis with the Atlanta classification: an interobserver agreement study. Pancreas 33 (4):331-335. https://doi.org/10.1097/01.mpa.0000240598.88193.8e

    Article  Google Scholar 

  21. van Santvoort HC, Bollen TL, Besselink MG, Banks PA, Boermeester MA, van Eijck CH, Evans J, Freeny PC, Grenacher L, Hermans JJ, Horvath KD, Hough DM, Lameris JS, van Leeuwen MS, Mortele KJ, Neoptolemos JP, Sarr MG, Vege SS, Werner J, Gooszen HG (2008) Describing peripancreatic collections in severe acute pancreatitis using morphologic terms: an international interobserver agreement study. Pancreatology 8 (6):593-599. https://doi.org/10.1159/000161010

    Article  PubMed  Google Scholar 

  22. Bollen TL, van Santvoort HC, Besselink MG, van Leeuwen MS, Horvath KD, Freeny PC, Gooszen HG, Dutch Acute Pancreatitis Study G (2008) The Atlanta Classification of acute pancreatitis revisited. Br J Surg 95 (1):6-21. https://doi.org/10.1002/bjs.6010

    Article  Google Scholar 

  23. Tenner S, Baillie J, DeWitt J, Vege SS, American College of G (2013) American College of Gastroenterology guideline: management of acute pancreatitis. Am J Gastroenterol 108 (9):1400-1415; 1416. https://doi.org/10.1038/ajg.2013.218

  24. Baker ME, Nelson RC, Rosen MP, Blake MA, Cash BD, Hindman NM, Kamel IR, Kaur H, Piorkowski RJ, Qayyum A, Yarmish GM (2014) ACR Appropriateness Criteria® acute pancreatitis. Ultrasound Q 30 (4):267-273. https://doi.org/10.1097/ruq.0000000000000099

    Article  PubMed  Google Scholar 

  25. Sharma V, Rana SS, Sharma RK, Gupta R, Bhasin DK (2015) Clinical outcomes and prognostic significance of early vs. late computed tomography in acute pancreatitis. Gastroenterol Rep (Oxf) 3 (2):144-147. https://doi.org/10.1093/gastro/gou067

    Article  Google Scholar 

  26. Jin DX, McNabb-Baltar JY, Suleiman SL, Wu BU, Khorasani R, Bollen TL, Banks PA, Singh VK (2017) Early Abdominal Imaging Remains Over-Utilized in Acute Pancreatitis. Dig Dis Sci 62 (10):2894-2899. https://doi.org/10.1007/s10620-017-4720-x

    Article  PubMed  Google Scholar 

  27. Garg PK, Singh VP (2019) Organ Failure due to Systemic Injury in Acute Pancreatitis. Gastroenterology. https://doi.org/10.1053/j.gastro.2018.12.041

    Article  PubMed  Google Scholar 

  28. Di MY, Liu H, Yang ZY, Bonis PA, Tang JL, Lau J (2016) Prediction Models of Mortality in Acute Pancreatitis in Adults: A Systematic Review. Ann Intern Med 165 (7):482-490. https://doi.org/10.7326/m16-0650

    Article  PubMed  Google Scholar 

  29. Zerem E (2014) Treatment of severe acute pancreatitis and its complications. World J Gastroenterol 20 (38):13879-13892. https://doi.org/10.3748/wjg.v20.i38.13879

    Article  PubMed  PubMed Central  Google Scholar 

  30. Working Group IAPAPAAPG (2013) IAP/APA evidence-based guidelines for the management of acute pancreatitis. Pancreatology 13 (4 Suppl 2):e1-15. https://doi.org/10.1016/j.pan.2013.07.063

    Article  Google Scholar 

  31. Ignatavicius P, Gulla A, Cernauskis K, Barauskas G, Dambrauskas Z (2017) How severe is moderately severe acute pancreatitis? Clinical validation of revised 2012 Atlanta Classification. World J Gastroenterol 23 (43):7785-7790. https://doi.org/10.3748/wjg.v23.i43.7785

    Article  PubMed  PubMed Central  Google Scholar 

  32. Dellinger EP, Forsmark CE, Layer P, Levy P, Maravi-Poma E, Petrov MS, Shimosegawa T, Siriwardena AK, Uomo G, Whitcomb DC, Windsor JA, Pancreatitis Across Nations Clinical R, Education A (2012) Determinant-based classification of acute pancreatitis severity: an international multidisciplinary consultation. Ann Surg 256 (6):875-880. https://doi.org/10.1097/sla.0b013e318256f778

    Article  Google Scholar 

  33. Nawaz H, Mounzer R, Yadav D, Yabes JG, Slivka A, Whitcomb DC, Papachristou GI (2013) Revised Atlanta and determinant-based classification: application in a prospective cohort of acute pancreatitis patients. Am J Gastroenterol 108 (12):1911-1917. https://doi.org/10.1038/ajg.2013.348

    Article  PubMed  Google Scholar 

  34. Yadav D (2014) Acute pancreatitis: too many classifications-what is a clinician or researcher to do? Clin Gastroenterol Hepatol 12 (2):317-319. https://doi.org/10.1016/j.cgh.2013.09.051

    Article  PubMed  Google Scholar 

  35. Badat N, Millet I, Corno L, Khaled W, Boulay-Coletta I, Zins M (2019) Revised Atlanta classification for CT pancreatic and peripancreatic collections in the first month of acute pancreatitis: interobserver agreement. Eur Radiol. https://doi.org/10.1007/s00330-018-5906-0

    Article  PubMed  Google Scholar 

  36. Bouwense SA, van Brunschot S, van Santvoort HC, Besselink MG, Bollen TL, Bakker OJ, Banks PA, Boermeester MA, Cappendijk VC, Carter R, Charnley R, van Eijck CH, Freeny PC, Hermans JJ, Hough DM, Johnson CD, Lameris JS, Lerch MM, Mayerle J, Mortele KJ, Sarr MG, Stedman B, Vege SS, Werner J, Dijkgraaf MG, Gooszen HG, Horvath KD, Acute Pancreatitis Interobserver Study G (2017) Describing Peripancreatic Collections According to the Revised Atlanta Classification of Acute Pancreatitis: An International Interobserver Agreement Study. Pancreas 46 (7):850-857. https://doi.org/10.1097/mpa.0000000000000863

    Article  PubMed  Google Scholar 

  37. Sternby H, Verdonk RC, Aguilar G, Dimova A, Ignatavicius P, Ilzarbe L, Koiva P, Lantto E, Loigom T, Penttila A, Regner S, Rosendahl J, Strahinova V, Zackrisson S, Zviniene K, Bollen TL (2016) Significant inter-observer variation in the diagnosis of extrapancreatic necrosis and type of pancreatic collections in acute pancreatitis - An international multicenter evaluation of the revised Atlanta classification. Pancreatology 16 (5):791-797. https://doi.org/10.1016/j.pan.2016.08.007

    Article  PubMed  Google Scholar 

  38. Zaheer A, Singh VK, Qureshi RO, Fishman EK (2013) The revised Atlanta classification for acute pancreatitis: updates in imaging terminology and guidelines. Abdom Imaging 38 (1):125-136. https://doi.org/10.1007/s00261-012-9908-0

    Article  PubMed  Google Scholar 

  39. Kamal A, Singh VK, Akshintala VS, Kawamoto S, Tsai S, Haider M, Fishman EK, Kamel IR, Zaheer A (2015) CT and MRI assessment of symptomatic organized pancreatic fluid collections and pancreatic duct disruption: an interreader variability study using the revised Atlanta classification 2012. Abdom Imaging 40 (6):1608-1616. https://doi.org/10.1007/s00261-014-0303-x

    Article  PubMed  Google Scholar 

  40. Koziel D, Gluszek S, Matykiewicz J, Lewitowicz P, Drozdzak Z (2015) Comparative analysis of selected scales to assess prognosis in acute pancreatitis. Can J Gastroenterol Hepatol 29 (6):299-303

    Article  Google Scholar 

  41. Harshit Kumar A, Singh Griwan M (2018) A comparison of APACHE II, BISAP, Ranson’s score and modified CTSI in predicting the severity of acute pancreatitis based on the 2012 revised Atlanta Classification. Gastroenterol Rep (Oxf) 6 (2):127-131. https://doi.org/10.1093/gastro/gox029

    Article  Google Scholar 

  42. He WH, Zhu Y, Zhu Y, Jin Q, Xu HR, Xion ZJ, Yu M, Xia L, Liu P, Lu NH (2017) Comparison of multifactor scoring systems and single serum markers for the early prediction of the severity of acute pancreatitis. J Gastroenterol Hepatol 32 (11):1895-1901. https://doi.org/10.1111/jgh.13803

    Article  CAS  PubMed  Google Scholar 

  43. Kuo DC, Rider AC, Estrada P, Kim D, Pillow MT (2015) Acute Pancreatitis: What’s the Score? J Emerg Med 48 (6):762-770. https://doi.org/10.1016/j.jemermed.2015.02.018

    Article  PubMed  Google Scholar 

  44. Vasudevan S, Goswami P, Sonika U, Thakur B, Sreenivas V, Saraya A (2018) Comparison of Various Scoring Systems and Biochemical Markers in Predicting the Outcome in Acute Pancreatitis. Pancreas 47 (1):65-71. https://doi.org/10.1097/mpa.0000000000000957

    Article  CAS  PubMed  Google Scholar 

  45. Hagjer S, Kumar N (2018) Evaluation of the BISAP scoring system in prognostication of acute pancreatitis - A prospective observational study. Int J Surg 54 (Pt A):76-81. https://doi.org/10.1016/j.ijsu.2018.04.026

    Article  PubMed  Google Scholar 

  46. Talukdar R, Bhattacharrya A, Rao B, Sharma M, Nageshwar Reddy D (2014) Clinical utility of the revised Atlanta classification of acute pancreatitis in a prospective cohort: have all loose ends been tied? Pancreatology 14 (4):257-262. https://doi.org/10.1016/j.pan.2014.06.003

    Article  PubMed  Google Scholar 

  47. Choi JH, Kim MH, Oh D, Paik WH, Park DH, Lee SS, Seo DW, Lee SK (2014) Clinical relevance of the revised Atlanta classification focusing on severity stratification system. Pancreatology 14 (5):324-329. https://doi.org/10.1016/j.pan.2014.08.001

    Article  PubMed  Google Scholar 

  48. Windsor JA, Johnson CD, Petrov MS, Layer P, Garg PK, Papachristou GI (2015) Classifying the severity of acute pancreatitis: towards a way forward. Pancreatology 15 (2):101-104. https://doi.org/10.1016/j.pan.2015.01.006

    Article  CAS  PubMed  Google Scholar 

Download references

Author information

Authors and Affiliations

Authors

Corresponding author

Correspondence to Kristin K. Porter.

Ethics declarations

Conflict of interest

The authors have no conflict of interest to disclose.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Colvin, S.D., Smith, E.N., Morgan, D.E. et al. Acute pancreatitis: an update on the revised Atlanta classification. Abdom Radiol 45, 1222–1231 (2020). https://doi.org/10.1007/s00261-019-02214-w

Download citation

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s00261-019-02214-w

Keywords

Navigation