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Association between chronic asymptomatic pancreatic hyperenzymemia and pancreatic ductal anomalies: a magnetic resonance cholangiopancreatography study

  • Pancreas
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Abstract

Purpose

Elucidating the association between pancreatic ductal anomalies and chronic asymptomatic pancreatic hyperenzymemia using magnetic resonance cholangiopancreatography.

Methods

We conducted a single-center, retrospective, case–control study. The healthy community group comprised 554 subjects who participated in a paid, whole-body health checkup program. The patient group comprised 14 subjects with idiopathic pancreatic hyperamylasemia or hyperlipasemia. All subjects underwent magnetic resonance cholangiopancreatography. The clinical features and incidence rates of pancreatic ductal anomalies were then compared between the groups.

Results

Compared to the healthy community group, the patient group was significantly more likely to be ≥ age 65 (71.4% of patient group vs. 22.1% of healthy community group), have a history of diabetes mellitus (21.4% vs. 5.4%) or hypertension (35.7% vs. 11.4%), and to have pancreas divisum (21.4% vs. 2.7%), meandering main pancreatic duct (21.4% vs. 4.1%), Wirsungocele (14.3% vs. 1.1%), or dilated main pancreatic duct (14.3% vs. 2.3%). Multivariate analysis found that age ≥ 65 (odds ratio 8.76), presence of pancreas divisum (odds ratio 13.2), meandering main pancreatic duct (odds ratio 8.95), and Wirsungocele (odds ratio 17.6) were independent factors significantly associated with chronic asymptomatic pancreatic hyperenzymemia.

Conclusions

Pancreas divisum, meandering main pancreatic duct, and Wirsungocele were independently associated with chronic asymptomatic pancreatic hyperenzymemia.

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Funding

This work was supported by JSPS KAKENHI Grant Number JP25870148.

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Authors and Affiliations

  1. Radiology, Graduate School of Medicine, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo, 113-8655, Japan

    Wataru Gonoi, Takana Yamakawa Hayashi & Osamu Abe

  2. Computational Diagnostic Radiology and Preventive Medicine, The University of Tokyo, Tokyo, Japan

    Naoto Hayashi

Authors
  1. Wataru Gonoi
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  2. Takana Yamakawa Hayashi
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  3. Naoto Hayashi
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  4. Osamu Abe
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Corresponding author

Correspondence to Wataru Gonoi.

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All authors have no conflict of interest to declare.

Ethical approval

Our Institutional Review Board approved this STROBE-compliant single-center retrospective case–control study.

Informed consent

Our Institutional Review Board waived informed consent for this STROBE-compliant single-center retrospective case–control study.

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We confirm that this study is STROBE-compliant.

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Gonoi, W., Hayashi, T.Y., Hayashi, N. et al. Association between chronic asymptomatic pancreatic hyperenzymemia and pancreatic ductal anomalies: a magnetic resonance cholangiopancreatography study. Abdom Radiol 44, 2494–2500 (2019). https://doi.org/10.1007/s00261-019-02004-4

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