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Abdominal Radiology

, Volume 44, Issue 2, pp 456–463 | Cite as

Diagnostic accuracy of F-18 FDG PET/CT for characterization of colorectal focal FDG uptake: a systematic review and meta-analysis

  • Gyung Mo Son
  • Seong-Jang KimEmail author
Article
  • 156 Downloads

Abstract

Introduction

We aimed to explore the role of the diagnostic accuracy of F-18 fluorodeoxyglucose positron emission tomography/computed tomography (PET/CT) for characterization of incidental colorectal focal FDG uptake through a systematic review and meta-analysis.

Methods

The MEDLINE, EMBASE, and Cochrane Library database, from the earliest available date of indexing through April 30, 2018, were searched for studies evaluating the diagnostic performance of F-18 FDG PET/CT for characterization of incidental colorectal focal FDG uptake. We determined the sensitivities and specificities across studies, calculated positive and negative likelihood ratios (LR+ and LR−), and constructed summary receiver operating characteristic curves.

Results

Across 8 studies (1451 patients), the pooled sensitivity for F-18 FDG PET/CT was 0.87 (95% CI 0.82–0.90) without heterogeneity (χ2 = 10.84, p = 0.37) and a pooled specificity of 0.83 (95% CI 0.76–0.89) with heterogeneity (χ2 = 130.1, p = 0.00). Likelihood ratio (LR) syntheses gave an overall positive likelihood ratio (LR+) of 5.2 (95% CI 3.6–7.4) and negative likelihood ratio (LR−) of 0.16 (95% CI 0.12–0.22). The pooled DOR was 32 (95% CI 20–51).

Conclusion

F-18 FDG PET/CT demonstrated good sensitivity and specificity for characterization of incidental colorectal focal FDG uptake. At present, the literature regarding the use of F-18 FDG PET/CT for characterization of incidental colorectal focal FDG uptake remains still limited; thus, further large multicenter studies would be necessary to substantiate the diagnostic accuracy of F-18 FDG PET/CT for characterization of incidental colorectal focal FDG uptake.

Keywords

Positron emission tomography PET/CT Colonic uptake Incidental 

Notes

Acknowledgements

This work was supported by a 2-Year Research Grant of Pusan National University.

Compliance with ethical standards

Conflict of interest

The authors of this manuscript declare no relationships with any companies whose products or services may be related to the subject matter of the article.

Ethical approval

Institutional review board approval was not required because we only performed data analysis based on the published studies.

Informed consent

Written informed consent was not required for this study because it is a meta-analysis based on the studies that have been published.

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of SurgeryPusan National University Yangsan HospitalYangsanKorea
  2. 2.BioMedical Research Institute for Convergence of Biomedical Science and TechnologyPusan National University Yangsan HospitalYangsanKorea
  3. 3.Department of Nuclear MedicinePusan National University Yangsan HospitalYangsanKorea

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