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Optimal method for measuring baseline metabolic tumor volume in DLBCL patients: are statistical agreements of SUV ≥2.5 satisfactory?

  • Eric Laffon
  • Roger Marthan
Letter to the Editor

Dear Editor,

The prognostic value of the pretreatment total metabolic tumor volume (TMTV) obtained from quantitative PET measurements in patients with diffuse large B cell lymphoma (DLBCL) may vary depending on the outlining method. Therefore, a standardized methodology for TMTV quantification is needed for multicenter studies. To this end, Ilyas et al. recently compared different TMTV measurement methods, including different software algorithms [1], to investigate agreement between (i) in-house and commercial software, (ii) different TMTV outlining methods and (iii) different observers. Receiver operating characteristic (ROC) curves were established to identify the optimal cut-off value for each TMTV method for predicting both progression-free survival (PFS) and overall survival (OS) in patients with DLBCL. Although all methods predicted prognosis, the authors concluded that the method using a lower standardized uptake value (SUV) threshold of 2.5 g mL−1(≥2.5 method) had the best...

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflict of interest.

Research involving human participants and/or animals

Not applicable.

Informed consent

Not applicable.

References

  1. 1.
    Ilyas H, Mikhaeel NG, Dunn JT, Rahman F, Møller H, Smith D, et al. Defining the optimal method for measuring baseline metabolic tumour volume in diffuse large B cell lymphoma. Eur J Nucl Med Mol Imaging. 2018.  https://doi.org/10.1007/s00259-018-3953-z.
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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.CHU de BordeauxBordeauxFrance
  2. 2.Univ. Bordeaux, Centre de Recherche Cardio-Thoracique de BordeauxBordeauxFrance
  3. 3.INSERM U-1045, Centre de Recherche Cardio-Thoracique de BordeauxBordeauxFrance
  4. 4.Service de Médecine NucléaireHôpital du Haut-LévèquePessacFrance

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