Interim FDG PET/CT in primary mediastinal diffuse large B-cell lymphoma: really almost useless procedure?

  • Vít Procházka
  • Lenka Henzlová
  • Jaroslav Ptáček
  • Tomáš Papajík
Letter to the Editor

Dear Sir,

We read with great interest the results of a retrospective analysis of interim FDG PET/CT in patients with primary mediastinal B-cell lymphoma (PMBCL) by Lazarovici et al. [1]. This paper could have an extraordinary impact on decision making in clinical practice worldwide. To investigate the prognostic value of interim PET in PMBCL, Lazarovici et al. analysed 36 consecutive patients who underwent PET/CT after four cycles of rituximab/anthracycline-containing regimens (mainly R-ACVBP or R-CHOP). They concluded that interim PET-positive results do not reflect persistence of active disease in the majority of patients. We fully agree with their statement that interim FDG PET/CT in PMBCL has a low positive prognostic value. But there are some major methodological drawbacks which should be clarified before one can accept that “the relapse rate appears similar regardless of interim FDG PET/CT results and interpretation criteria”, as the authors claimed.

First, the PET results were...


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Conflicts of interest


Ethical approval

This article does not describe any studies with human participants performed by any of the authors.


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© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Department of Hemato-Oncology, Faculty of Medicine and DentistryPalacky UniversityOlomoucCzech Republic
  2. 2.PET Imaging Center, Department of Nuclear Medicine, Faculty of Medicine and DentistryPalacky UniversityOlomoucCzech Republic

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