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Head to head comparison of [18F] AV-1451 and [18F] THK5351 for tau imaging in Alzheimer’s disease and frontotemporal dementia

  • Young Kyoung Jang
  • Chul Hyoung Lyoo
  • Seongbeom Park
  • Seung Jun Oh
  • Hanna Cho
  • Minyoung Oh
  • Young Hoon Ryu
  • Jae Yong Choi
  • Gil D. Rabinovici
  • Hee Jin Kim
  • Seung Hwan Moon
  • Hyemin Jang
  • Jin San Lee
  • William J. Jagust
  • Duk L. Na
  • Jae Seung Kim
  • Sang Won Seo
Original Article

Abstract

Purpose

Tau accumulation is a core pathologic change in various neurodegenerative diseases including Alzheimer’s disease and frontotemporal lobar degeneration-tau. Recently, tau positron emission tomography tracers such as [18F] AV-1451 and [18F] THK5351 have been developed to detect tau deposition in vivo. In the present study, we performed a head to head comparison of these two tracers in Alzheimer’s disease and frontotemporal dementia cases and aimed to investigate which tracers are better suited to image tau in these disorders.

Methods

A cross-sectional study was conducted using a hospital-based sample at a tertiary referral center. We recruited eight participants (two Alzheimer’s disease, four frontotemporal dementia and two normal controls) who underwent magnetic resonance image, amyloid positron emission tomography with [18F]-Florbetaben and tau positron emission tomography with both THK5351 and AV-1451. To measure regional AV1451 and THK5351 uptakes, we used the standardized uptake value ratios by dividing mean activity in target volume of interest by mean activity in the cerebellar hemispheric gray matter.

Results

Although THK5351 and AV-1451 uptakes were highly correlated, cortical uptake of AV-1451 was more striking in Alzheimer’s disease, while cortical uptake of THK5351 was more prominent in frontotemporal dementia. THK5351 showed higher off-target binding than AV-1451 in the white matter, midbrain, thalamus, and basal ganglia.

Conclusions

AV-1451 is more sensitive and specific to Alzheimer’s disease type tau and shows lower off-target binding, while THK5351 may mirror non-specific neurodegeneration.

Keywords

Tau Av-1451 THK5351 Alzheimer’s disease Frontotemporal dementia 

Notes

Funding

This research was supported by a grant from the Korea Health Technology R&D Project through the Korea Health Industry Development Institute (KHIDI), funded by the Ministry of Health & Welfare, Republic of Korea (HI14C2768); and the National Research Foundation of Korea (NRF) grant funded by the Korea government (MSIP) (No. NRF-2017R1A2B2005081).

Compliance with ethical standards

Conflict of interest

G.D.R. receives research support from Avid Radiopharmaceuticals, Eli Lilly, GE Healthcare and Piramal. He has received consulting fees and speaking honoraria from Eisai, Genentech, Roche, Lundbeck, Putnam and Merck.

Role of the funder

The funders had no role in the design and conduct of the study; collection, management, analysis, and interpretation of the data; preparation, review, or approval of the manuscript; or decision to submit the manuscript for publication.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

Informed consent

Informed consent was obtained from all individual participants included in the study.

Supplementary material

259_2017_3876_MOESM1_ESM.docx (18 kb)
ESM 1 (DOCX 17.7 kb).
259_2017_3876_MOESM2_ESM.docx (249 kb)
ESM 2 (DOCX 248 kb).

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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2017

Authors and Affiliations

  • Young Kyoung Jang
    • 1
    • 2
  • Chul Hyoung Lyoo
    • 3
  • Seongbeom Park
    • 1
  • Seung Jun Oh
    • 4
  • Hanna Cho
    • 3
  • Minyoung Oh
    • 4
  • Young Hoon Ryu
    • 5
  • Jae Yong Choi
    • 5
  • Gil D. Rabinovici
    • 6
    • 7
  • Hee Jin Kim
    • 1
    • 2
  • Seung Hwan Moon
    • 8
  • Hyemin Jang
    • 1
    • 2
  • Jin San Lee
    • 9
  • William J. Jagust
    • 7
    • 10
  • Duk L. Na
    • 1
    • 2
    • 11
  • Jae Seung Kim
    • 4
  • Sang Won Seo
    • 1
    • 2
    • 11
    • 12
  1. 1.Department of Neurology, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea
  2. 2.Neuroscience Center, Samsung Medical CenterSeoulSouth Korea
  3. 3.Department of Neurology, Gangnam Severance HospitalYonsei University College of MedicineSeoulSouth Korea
  4. 4.Department of Nuclear Medicine, Asan Medical CenterUniversity of Ulsan College of MedicineSeoulSouth Korea
  5. 5.Department of Nuclear Medicine, Gangnam Severance HospitalYonsei University College of MedicineSeoulSouth Korea
  6. 6.Memory and Aging CenterUniversity of California, San FranciscoSan FranciscoUSA
  7. 7.Helen Wills Neuroscience InstituteUniversity of California, BerkeleyBerkeleyUSA
  8. 8.Department of Nuclear Medicine, Samsung Medical CenterSungkyunkwan University School of MedicineSeoulSouth Korea
  9. 9.Department of NeurologyKyung Hee University HospitalSeoulSouth Korea
  10. 10.Center of Functional ImagingLawrence Berkeley National LaboratoryBerkeleyUSA
  11. 11.Department of Health Sciences and Technology, SAIHSTSungkyunkwan UniversitySeoulSouth Korea
  12. 12.Department of Clinical Research Design & Evaluation, SAIHSTSungkyunkwan UniversitySeoulSouth Korea

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