Relation between thoracic aortic inflammation and features of plaque vulnerability in the coronary tree in patients with non-ST-segment elevation acute coronary syndrome undergoing percutaneous coronary intervention. An FDG-positron emission tomography and optical coherence tomography study

  • Nevio Taglieri
  • Cristina Nanni
  • Gabriele Ghetti
  • Rachele Bonfiglioli
  • Francesco Saia
  • Maria Letizia Bacchi Reggiani
  • Giacomo Maria Lima
  • Valeria Marco
  • Francesco Prati
  • Stefano Fanti
  • Claudio Rapezzi
Original Article

Abstract

Purpose

To evaluate the relationship between aortic inflammation as assessed by 18F–fluorodeoxyglucose-positron emission tomography (18F–FDG-PET) and features of plaque vulnerability as assessed by frequency domain-optical coherence tomography (FD-OCT).

Methods

We enrolled 30 consecutive non-ST-segment elevation acute coronary syndrome patients undergoing percutaneous coronary intervention. All patients underwent three-vessel OCT before intervention and 18F–FDG-PET before discharge. Univariable and C-reactive protein (CRP)-adjusted linear regression analyses were performed between features of vulnerability [namely:lipid-rich plaques with and without macrophages and thin cap fibroatheromas (TCFA)] and 18F–FDG uptake in both ascending (AA) and descending aorta (DA) [measured either as averaged mean and maximum target-to-blood ratio (TBR) or as active slices (TBRmax ≥ 1.6)].

Results

Mean age was 62 years, and 26 patients were male. On univariable linear regression analysis TBRmean and TBRmax in DA was associated with the number of lipid-rich plaques (β = 4.22; 95%CI 0.05–8.39; p = 0.047 and β = 3.72; 95%CI 1.14–6.30; p = 0.006, respectively). TBRmax in DA was also associated with the number of lipid-rich plaques containing macrophages (β = 2.40; 95%CI 0.07–4.72; p = 0.044). A significant CRP adjusted linear association between the TBRmax in DA and the number of lipid-rich plaques was observed (CRP-adjusted β = 3.58; 95%CI -0.91-6.25; p = 0.01). TBRmax in DA showed a trend towards significant CRP-adjusted association with number of lipid-rich plaques with macrophages (CRP-adjusted β = 2.30; 95%CI -0.11-4.71; p = 0.06). We also observed a CRP-adjusted (β = 2.34; 95%CI 0.22–4.47; p = 0.031) linear association between the number of active slices in DA and the number of lipid-rich plaques. No relation was found between FDG uptake in the aorta and the number of TCFAs.

Conclusions

In patients with first NSTEACS, 18F–FDG uptake in DA is correlated with the number of OCT detected lipid-rich plaques with or without macrophages. This association may be independent from CRP values.

Keywords

18F–fluorodeoxyglucose-positron emission tomography Frequency domain-optical coherence tomography Non ST-segment elevation acute coronary syndrome 

Supplementary material

259_2017_3747_MOESM1_ESM.docx (13 kb)
Table S1(DOCX 13 kb)

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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • Nevio Taglieri
    • 1
  • Cristina Nanni
    • 2
  • Gabriele Ghetti
    • 1
  • Rachele Bonfiglioli
    • 2
  • Francesco Saia
    • 1
  • Maria Letizia Bacchi Reggiani
    • 1
  • Giacomo Maria Lima
    • 2
  • Valeria Marco
    • 3
  • Francesco Prati
    • 3
    • 4
  • Stefano Fanti
    • 2
  • Claudio Rapezzi
    • 1
  1. 1.Istituto di Cardiologia, Dipartimento di Medicina Specialistica, Diagnostica e SperimentaleAlma Mater Studiorum Università di BolognaBolognaItaly
  2. 2.Istituto di Medicina Nucleare, Dipartimento di Medicina Specialistica, Diagnostica e SperimentaleAlma Mater Studiorum Università di BolognaBolognaItaly
  3. 3.CLI FoundationRomeItaly
  4. 4.GVM Care & ResearchEttore Sansavini Health Science FoundationCotignolaItaly

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