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Skeletal Radiology

, Volume 47, Issue 8, pp 1191–1192 | Cite as

Chest wall mass in a 15-year-old female patient

  • Michael Khoo
  • Ian Pressney
  • Rikin Hargunani
  • John Skinner
  • Asif Saifuddin
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Discussion

Diffuse lipomatosis (DL) is a rare disorder compromising diffuse mature adipose tissue overgrowth [1, 2]. The term lipomatosis is used where the fatty lesion involves multiple tissues [3].

In the pediatric age group, this usually presents under the age of 2 and commonly affects the face and neck. However, presentation can also occur in adolescents and, rarely, in adults where the anatomical involvement also includes the limbs and trunk. It is locally infiltrative but when involving the musculoskeletal system, is usually confined to the superficial soft tissues of skin, subcutaneous and muscle layers, but sparing the nerves.

Clinical features depend on the location and size of the lesion but mainly consist of cosmetic deformity and localized mechanical symptoms due to compression of adjacent structures. Rapid growth may occur and cause the clinical concern of a neoplastic process; if biopsy is performed, the histopathology findings are of mature adipose tissue.

Imaging plays an important role in diagnosis. MRI allows high soft tissue resolution to define the complete and homogenous fatty nature of diffuse lipomatosis, (Fig. 2 a–d) differentiating it from other non-aggressive but more heterogenous fat-containing lesions (lipoblastoma and angiolipoma amongst others) and also highlighting, if necessary, any potential concerning components requiring biopsy for histopathological evaluation. Thin linear low signal strands within the fatty lesion of our case most likely represent a combination of fibrous bands and fibers from the intercostal muscles, which is an expected finding where DL involves local musculature.

MRI also allows assessment of involvement of local anatomical structures which can differentiate lipomatosis from other pathologies to be considered in the differential diagnosis. Assessment of the local nerves is important, as there is no neural involvement in lipomatosis. Any fatty or non-fatty neural abnormality would change the potential diagnosis and other pathologies would need to be considered, such as lipomatosis of the nerve, but also potentially include pathologies of neurogenic origin such as neurofibromatosis.

Features on radiographs are typically of focal low-density soft tissue overgrowth (Fig. 1) with potential splaying of adjacent osseous structures, in this case of the ribs, depending on the anatomical location.

In our case, there is the rare association of local osseous overgrowth. On plain radiography, there is focal enlargement of the left 4th rib with a low density surrounding this and splaying of the adjacent 3rd and 5th ribs (Fig. 1). MRI (Fig. 2a–d) demonstrates a large mass of lipomatous signal surrounding the enlarged left 4th rib, which retains normal bone marrow signal.

Osseous overgrowth has been previously noted in relation to lipomatous lesions [4] but they are rare and little has been published, with their overall incidence and the pathogenesis of the lipoma-bone abnormality remaining unclear [5]. Where there is osseous overgrowth by a lipomatous lesion, careful assessment of the bone involved should be undertaken to ensure the changes are not arising from the bone itself. For instance, involvement of the cortex could potentially suggest a parosteal lipoma.

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

References

  1. 1.
    Fletcher C, Unni K, Mertens F. World Health Organisation Classification of Tumors of Soft Tissue and Bone. International Agency for Research on Cancer: Lyon; 2013.Google Scholar
  2. 2.
    Murphey MD, Fairbairn KJ, Parman LM, Baxter KG, Parsa MB, Smith WS. From the archives of the AFIP. Musculoskeletal angiomatous lesions: radiologic-pathologic correlation. Radiogr Rev Publ Radiol Soc N Am Inc. 1995;15:893–917.Google Scholar
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    Bancroft LW, Kransdorf MJ, Peterson JJ, O’Connor MI. Benign fatty tumors: classification, clinical course, imaging appearance, and treatment. Skelet Radiol. 2006;35:719–33.CrossRefGoogle Scholar
  4. 4.
    Sauer JM, Ozonoff MB. Congenital bone anomalies associated with lipomas. Skelet Radiol. 1985;13:276–9.CrossRefGoogle Scholar
  5. 5.
    Kransdorf M, Murphey M. Lipomatous tumours. Imaging Soft Tissue Tumours. Philadelphia: Saunders; 1997. p. 57–101.Google Scholar

Copyright information

© ISS 2018

Authors and Affiliations

  • Michael Khoo
    • 1
  • Ian Pressney
    • 1
  • Rikin Hargunani
    • 1
  • John Skinner
    • 2
  • Asif Saifuddin
    • 1
  1. 1.Department of RadiologyRoyal National Orthopaedic HospitalMiddlesexUK
  2. 2.Department of Orthopaedic SurgeryRoyal National Orthopaedic HospitalMiddlesexUK

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