Skeletal Radiology

, Volume 47, Issue 8, pp 1043–1050 | Cite as

Fibrodysplasia ossificans progressiva: a current review of imaging findings

  • Adam H. Bauer
  • Jeff Bonham
  • Luis Gutierrez
  • Edward C. Hsiao
  • Daria Motamedi
Review Article



Fibrodysplasia ossificans progressiva is a rare genetic disorder characterized by congenital skeletal deformities and soft tissue masses that progress to heterotopic ossification. Deformities of the great toes are distinctive, and heterotopic ossification in the soft tissues follows an expected anatomic and temporal pattern. In addition to heterotopic ossification, osteochondromata, middle ear ossification, demyelination, lymphedema, and venous thrombosis are characteristic. Awareness of this constellation of findings is important to early diagnosis and surveillance.


Recognition of the imaging manifestations of fibrodysplasia ossificans progressiva is imperative to early diagnosis in order to appropriately direct patient care and preclude unnecessary biopsies or surgical procedures.


Fibrodysplasia ossificans progressiva Heterotopic ossification FOP Skeletal development Myositis ossificans progressiva Genetic disorder 


Compliance with ethical standards


Edward C. Hsiao receives clinical research funding from Clementia Pharmaceuticals to support clinical trials in FOP. This does not pose a conflict of interest for this project.

Conflict of interest

The authors declare that they have no conflicts of interest.


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Copyright information

© ISS 2018

Authors and Affiliations

  • Adam H. Bauer
    • 1
  • Jeff Bonham
    • 2
  • Luis Gutierrez
    • 2
  • Edward C. Hsiao
    • 3
  • Daria Motamedi
    • 2
  1. 1.Kaiser Fontana Medical CenterFontanaUSA
  2. 2.Department of Radiology and Biomedical ImagingUniversity of CaliforniaSan FranciscoUSA
  3. 3.Division of Endocrinology, Diabetes, and Metabolism and the Institute for Human Genetics, Department of MedicineUniversity of CaliforniaSan FranciscoUSA

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