Advertisement

Skeletal Radiology

, Volume 47, Issue 4, pp 579–585 | Cite as

Parosteal extra-axial chordoma of the second metacarpal bone: a case report with literature review

  • Shinji Tsukamoto
  • Daniel Vanel
  • Alberto Righi
  • Davide Maria Donati
  • Costantino Errani
Case Report

Abstract

Extra-axial chordoma is a chordoma that occurs in non-axial locations. It is a very rare tumor, with 20 cases reported to date; 14 in bone and six in soft tissue. Of the 14 skeletal extra-axial chordomas, ten were intramedullary and four were intracortical. We report the first case of parosteal extra-axial chordoma arising in the second metacarpal bone, expressing brachyury on immunohistochemical analysis, and describe the pathologic and radiologic findings. We suggest that extra-axial chordoma can occur in parosteal bone lesions or the hand, without features of bone distribution or bone-specific sites.

Keywords

Chordoma Parachordoma Extra-axial chordoma Brachyury Metacarpal bone Parosteal 

Notes

Compliance with ethical standards

Conflict of interest

The authors declare that they have no conflicts of interest.

Author statement

All authors had access to data and a role in writing the manuscript.

References

  1. 1.
    Fletcher CDM, Bridge JA, Hogendoorn P, Mertens F. WHO Classification of Tumours of Soft Tissue and Bone. Lyon: IARC; 2013.Google Scholar
  2. 2.
    Yamaguchi T, Watanabe-Ishiiwa H, Suzuki S, Igarashi Y, Ueda Y. Incipient chordoma: a report of two cases of early-stage chordoma arising from benign notochordal cell tumors. Mod Pathol. 2005;18(7):1005–10.CrossRefPubMedGoogle Scholar
  3. 3.
    Tirabosco R, Mangham DC, Rosenberg AE, et al. Brachyury expression in extra-axial skeletal and soft tissue chordomas: a marker that distinguishes chordoma from mixed tumor/myoepithelioma/parachordoma in soft tissue. Am J Surg Pathol. 2008;32(4):572–80.CrossRefPubMedGoogle Scholar
  4. 4.
    Imai R, Kamada T, Tsuji H, Yanagi T, Baba M, Miyamoto T, et al. Carbon ion radiotherapy for unresectable sacral chordomas. Clin Cancer Res. 2004;10(17):5741–6.CrossRefPubMedGoogle Scholar
  5. 5.
    Suzuki H, Yamashiro K, Takeda H, Nojima T, Usui M. Extra-axial soft tissue chordoma of wrist. Pathol Res Pract. 2011;207(5):327–31.CrossRefPubMedGoogle Scholar
  6. 6.
    Nielsen GP, Mangham DC, Grimer RJ, Rosenberg AE. Chordoma periphericum: a case report. Am J Surg Pathol. 2001;25(2):263–7.CrossRefPubMedGoogle Scholar
  7. 7.
    van Akkooi AC, van Geel AN, Bessems JH, den Bakker MA. Extra-axial chordoma. J Bone Joint Surg Br. 2006;88(9):1232–4.CrossRefPubMedGoogle Scholar
  8. 8.
    DiFrancesco LM, Davanzo Castillo CA, Temple WJ. Extra-axial chordoma. Arch Pathol Lab Med. 2006;130(12):1871–4.PubMedGoogle Scholar
  9. 9.
    O'Donnell P, Tirabosco R, Vujovic S, et al. Diagnosing an extra-axial chordoma of the proximal tibia with the help of brachyury, a molecule required for notochordal differentiation. Skelet Radiol. 2007;36(1):59–65.CrossRefGoogle Scholar
  10. 10.
    DeComas AM, Penfornis P, Harris MR, Meyer MS, Pochampally RR. Derivation and characterization of an extra-axial chordoma cell line (EACH-1) from a scapular tumor. J Bone Joint Surg Am. 2010;92(5):1231–40.CrossRefPubMedGoogle Scholar
  11. 11.
    Lantos JE, Agaram NP, Healey JH, Hwang S. Recurrent skeletal extra-axial chordoma confirmed with brachyury: imaging features and review of the literature. Skelet Radiol. 2013;42(10):1451–9.CrossRefGoogle Scholar
  12. 12.
    Rekhi B. Primary, large extra-axial chordoma in proximal tibia: a rare case report with literature review and diagnostic implications. APMIS. 2016;124(3):238–42.CrossRefPubMedGoogle Scholar
  13. 13.
    Evans S, Khan Z, Jeys L, Grimer R. Extra-axial chordomas. Ann R Coll Surg Engl. 2016;98(5):324–8.CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Robinson P, White LM, Sundaram M, et al. Periosteal chondroid tumors: radiologic evaluation with pathologic correlation. Am J Roentgenol. 2001;177:1183–8.CrossRefGoogle Scholar
  15. 15.
    Nakatani T, Yamamoto T, Akisue T, et al. Periosteal osteoblastoma of the distal femur. Skelet Radiol. 2004;33:107–11.CrossRefGoogle Scholar
  16. 16.
    Azouz EM, Saigal G, Rodriguez MM, Podda A. Langerhans cell histiocytosis: pathology, imaging and treatment of skeletal involvement. Pediatr Radiol. 2005;35:103–15.CrossRefPubMedGoogle Scholar
  17. 17.
    Alberghini M, Pasquinelli G, Zanella L, et al. Primary malignant myoepithelioma of the distal femur. APMIS. 2007;115(4):376–80.CrossRefPubMedGoogle Scholar
  18. 18.
    Lin CY, Kao CH, Liang JA, Hsieh TC, Yen KY, Sun SS. Chordoma detected on F-18 FDG PET. Clin Nucl Med. 2006;31(8):506–7.CrossRefPubMedGoogle Scholar
  19. 19.
    Park SA, Kim HS. F-18 FDG PET/CT evaluation of sacrococcygeal chordoma. Clin Nucl Med. 2008;33(12):906–8.CrossRefPubMedGoogle Scholar
  20. 20.
    Miyazawa N, Ishigame K, Kato S, Satoh Y, Shinohara T. Thoracic chordoma: review and role of FDG-PET. J Neurosurg Sci. 2008;52(4):117–21. discussion 121–2PubMedGoogle Scholar
  21. 21.
    Figl M, Leixnering M. Retrospective review of outcome after surgical treatment of enchondromas in the hand. Arch Orthop Trauma Surg. 2009;129(6):729–34.CrossRefPubMedGoogle Scholar
  22. 22.
    Morris CJ, Younan Y, Singer AD, Johnson G, Chamieh J, Datir A. Masses of the hand and wrist, a pictorial review. Clin Imaging. 2016;40(4):650–65.CrossRefPubMedGoogle Scholar
  23. 23.
    Athanasian EA. Bone and soft tissue tumors. In: Hotchkiss RN, Pederson WC, Wolfe SH, Kozen SH, editors. Green’s operative hand surgery. 6th ed. Philadelphia: Elsevier Health; 2010.Google Scholar
  24. 24.
    Payne WT, Merrell G. Benign bony and soft tissue tumors of the hand. J Hand Surg Am. 2010;35(11):1901–10.CrossRefPubMedGoogle Scholar
  25. 25.
    Henderson M, Neumeister MW, Bueno RA Jr. Hand tumors: II. Benign and malignant bone tumors of the hand. Plast Reconstr Surg. 2014;133(6):814e–21e.CrossRefPubMedGoogle Scholar
  26. 26.
    Melamud K, Drapé JL, Hayashi D, Roemer FW, Zentner J, Guermazi A. Diagnostic imaging of benign and malignant osseous tumors of the fingers. Radiographics. 2014;34(7):1954–67.CrossRefPubMedGoogle Scholar
  27. 27.
    Miller TT. Bone tumors and tumor like conditions: analysis with conventional radiography. Radiology. 2008;246(3):662–74.CrossRefPubMedGoogle Scholar

Copyright information

© ISS 2017

Authors and Affiliations

  • Shinji Tsukamoto
    • 1
  • Daniel Vanel
    • 2
  • Alberto Righi
    • 2
  • Davide Maria Donati
    • 1
  • Costantino Errani
    • 1
  1. 1.Department of Orthopaedic OncologyRizzoli InstituteBolognaItaly
  2. 2.Department of PathologyRizzoli InstituteBolognaItaly

Personalised recommendations