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POEMS syndrome: radiographic appearance with MRI correlation

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Abstract

POEMS syndrome is a rare disorder in which patients present with the hallmark signs of polyneuropathy, organomegaly, endocrinopathy, M protein and skin changes. Many other clinical findings are also often present, most notably osseous lesions. The MRI appearance of the bony lesions in POEMS syndrome has been described in five cases, four of which are in the non-English literature. We report the MRI appearance of the osseous lesions in a patient with POEMS syndrome who presented with sciatic neuropathy.

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References

  1. Dispenzieri A, Kyle RA, Lacy MQ, et al. POEMS syndrome: definitions and long-term outcome, Blood 2003; 101:2496–2506.

    Article  CAS  Google Scholar 

  2. Resnick D. Bone and joint imaging, 4th edn. Philadelphia: WB Saunders, 2002:2188.

  3. Michel JL, Gaucher-Hugel AS, Reynier C, Lhoste A, Phileppe P. POEMS syndrome: imaging of skeletal manifestations, a study of 8 cases. J Radiol 2003; 84393–397 (in French).

  4. Kim JW, Lee SK, HA KM, Kim KH, Joh GY, Kim HJ, Yang SO. POEMS syndrome: a case report. J Korean Med Sci 1992; 7:79–84 (in Korean).

    Article  CAS  Google Scholar 

  5. Furuzono H, Moritoyo T, Yamada H, Sugihara R, Nagamatsu K. A case of Crow-Fukase syndrome which developed seven years following myelopathy of unknown origin. Rinsho Shinkeigu 1993; 33:56–60 (in Japanese).

    CAS  Google Scholar 

  6. Brazis PW, Liesegang TJ, Bolling JP, Kashii S, Trachtman M, Burde RM. When do optic disc edema and peripheral neuropathy constitute poetry? Surv Ophthalmol 1990; 35:219–225.

    Article  CAS  Google Scholar 

  7. Stokes SH, Griffith RC, Thomas PR. Angiofollicular lymph node hyperplasia (Castleman’s disease) associated with vertebral destruction. Cancer 1985; 56:876–879.

    Article  CAS  Google Scholar 

  8. Bendszus M, Wessig C, Solymosi L, Reiners K, Koltzenburg M. MRI of peripheral nerve degeneration and regeneration: correlation with electrophysiology and histology. Exp Neurol 2004; 188:171–177.

    Article  Google Scholar 

  9. Resnick D, Greenway GD, Bardwick PA, Zvaifer NJ, Gill GN. Plasma-cell dyscrasia with polyneuropathy, organomegaly, endocrinopathy, M-protein, and skin changes: the POEMS syndrome. Radiology 1981; 140:17–22.

    Article  CAS  Google Scholar 

  10. Bessler W, Antonucci F, Stamm B, Stuckmann G, Vollrath T. Case report 646. POEMS syndrome. Skeletal Radiol 1991; 20:212–215.

    Article  CAS  Google Scholar 

  11. Brandon C, Martel W, Weatherbee L, Capek P. Case report 572. Osteosclerotic myeloma (POEMS) syndrome. Skeletal Radiol 1989; 18:542–546.

    Article  CAS  Google Scholar 

  12. Narvaez JA, Majos C, Narvaez J, Valls C, Fernandez-Cabrera L. POEMS syndrome: unusual radiographic, scintigraphic and CT features. Eur Radiol 1998; 8:134–136.

    Article  CAS  Google Scholar 

  13. Mulleman D, Gaxatte C, Guillerm G, et al. Multiple myeloma presenting with widespread osteosclerotic lesions. Joint Bone Spine 2004; 71:79–83.

    Article  Google Scholar 

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Acknowledgements

We would like to thank Michael Spearman, M.D. and Kevin Mahood, MBA, RT from the Department of Radiology at The Western Pennsylvania Hospital and Emanuel Kanal, M.D., FACR from the University of Pittsburgh Medical Center for their insightful contributions to this case.

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Correspondence to Suzanne T. Chong.

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Chong, S.T., Beasley, H.S. & Daffner, R.H. POEMS syndrome: radiographic appearance with MRI correlation. Skeletal Radiol 35, 690–695 (2006). https://doi.org/10.1007/s00256-005-0941-8

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  • DOI: https://doi.org/10.1007/s00256-005-0941-8

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