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Naturally occurring of α,β-diepoxy-containing compounds: origin, structures, and biological activities

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Abstract

Diepoxy-containing compounds are widely distributed in nature. These metabolites are found in plants and marine organisms and are also produced by many microorganisms, fungi, or fungal endophytes. Many of these metabolites are antibiotics and exhibit a wide variety of biological activities. More than 80 α,β-diepoxy-containing compounds are presented in this article, which belong to different classes of chemical compounds including lipids, terpenoids, alkaloids, quinones, hydroquinones, and pyrones. The main activities that characterize α,β-diepoxy-containing compounds are antineoplastic with confidence up to 99%, antifungal with confidence up to 94%, antiinflammatory with confidence up to 92%, or antibacterial with confidence up to 78%. In addition, these metabolites can be used as a lipid metabolism regulator with a certainty of up to 81%, antiviral (Arbovirus) activity with a certainty of up to 71%, or antiallergic activity with confidence up to 69%. These data on the biological activity of diepoxy-containing compounds are of considerable interest to pharmacologists, chemists, and medical professionals who are involved in phytomedicine and related areas of science and industry.

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Acknowledgements

The work was performed in the framework of the Program for Basic Research of Russian State Academies of Sciences for 2013-2020 (Grant RFBR No. 12-04-91,445).

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Authors and Affiliations

  1. N.D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, Leninsky Prospect 47, Moscow, Russia, 119991

    Vera Vil, Alexander O. Terent’ev & Valery M. Dembitsky

  2. Institute of Biomedical Chemistry, Russian Academy of Sciences, Moscow, Russia, 119121

    Tatyana A. Gloriozova & Vladimir V. Poroikov

  3. Centre for Applied Research and Innovation, Lethbridge College, 3000 College Drive South, Lethbridge, AB, T1K 1L6, Canada

    Nick Savidov & Valery M. Dembitsky

  4. National Scientific Center of Marine Biology, Vladivostok, Russia, 690041

    Valery M. Dembitsky

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  1. Vera Vil
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  2. Tatyana A. Gloriozova
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  3. Vladimir V. Poroikov
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  4. Alexander O. Terent’ev
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  5. Nick Savidov
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  6. Valery M. Dembitsky
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Correspondence to Valery M. Dembitsky.

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Vil, V., Gloriozova, T.A., Poroikov, V.V. et al. Naturally occurring of α,β-diepoxy-containing compounds: origin, structures, and biological activities. Appl Microbiol Biotechnol 103, 3249–3264 (2019). https://doi.org/10.1007/s00253-019-09711-4

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