Abstract
Prodiginines are a large family of tripyrrole alkaloids that contain natural members produced by various bacteria and non-natural members obtained from chemical synthesis, enzymatic synthesis, and mutasynthesis. These compounds have attracted a great deal of attention due to their wide range of fascinating properties including anti-infective, anticancer, and immunosuppressive activities. In consideration of the great need for novel and effective anti-infective agents, this review is mainly focused on the current status of research on the anti-infective properties of prodiginines, highlighting their antibacterial, antifungal, antiprotozoal, anti-larval, and antiviral activities. Additionally, the multiple mechanisms by which prodiginines exert their anti-infective effects will also be discussed.
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This work was financially supported by the Zhejiang Provincial Natural Science Foundation of China (No. LQ14C050002), Project of Jiaxing Science and Technology (2017AY33087).
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You, Z., Zhang, S., Liu, X. et al. Insights into the anti-infective properties of prodiginines. Appl Microbiol Biotechnol 103, 2873–2887 (2019). https://doi.org/10.1007/s00253-019-09641-1
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DOI: https://doi.org/10.1007/s00253-019-09641-1