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Recent progress on biological production of α-arbutin

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Abstract

Arbutin, a glucoside of hydroquinone, is used as a powerful skin lightening agent in the cosmeceutical industry because of its strong inhibitory effect on the human tyrosinase activity. It is a natural compound occurring in a number of plants, with a β-anomeric form of the glycoside bond between glucose and hydroquinone. α-Arbutin, which glycoside bond is generated with α-anomeric form, is the isomer of natural arbutin. α-Arbutin is generally produced by transglucosylation of hydroquinone by microbial glycosyltransferases. It is interesting that α-arbutin is found to be over 10 times more effective than arbutin, and thus biological production of α-arbutin attracts increasing attention. Seven different microbial enzymes have been identified to be able to produce α-arbutin, including α-amylase, sucrose phosphorlase, cyclodextrin glycosyltransferase, α-glucosidase, dextransucrase, amylosucrase, and sucrose isomerase. In this work, enzymatic and microbial production of α-arbutin is reviewed in detail.

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Acknowledgements

This work was supported by the Support Project of Jiangsu Province (No. 2015-SWYY-009), the Research Program of State Key Laboratory of Food Science and Technology, Jiangnan University (Nos. SKLF-ZZA-201802 and SKLF-ZZB-201814), and the National First-Class Discipline Program of Food Science and Technology (No. JUFSTR20180203).

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  1. State Key Laboratory of Food Science and Technology, Jiangnan University, Wuxi, 214122, Jiangsu, China

    Xingtong Zhu, Yuqing Tian, Wenli Zhang, Tao Zhang, Cuie Guang & Wanmeng Mu

  2. International Joint Laboratory on Food Safety, Jiangnan University, Wuxi, 214122, China

    Tao Zhang & Wanmeng Mu

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  1. Xingtong Zhu
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  2. Yuqing Tian
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  3. Wenli Zhang
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Correspondence to Wanmeng Mu.

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Zhu, X., Tian, Y., Zhang, W. et al. Recent progress on biological production of α-arbutin. Appl Microbiol Biotechnol 102, 8145–8152 (2018). https://doi.org/10.1007/s00253-018-9241-9

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