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The role of laboratory-scale bioreactors at the semi-continuous and continuous microbiological and biotechnological processes

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Abstract

Laboratory-scale bioreactors represent an important part of microbiological, biotechnological, and biochemical researches. The small volume bioreactors enable the biomass growth, extracellular metabolite production, solid-state fermentation, and biocatalytic processes in a controlled open system. Using the lab-scale bioreactors, the processes which were optimized in experiments can be scaled up to a pilot level. In turn, the manufacturing scale processes can be scaled down to study the heterogeneity of the system and its effect on the producer. This mini-review is focused on a short description of features of the most popular designs of continuous and semi-continuous bioreactors applied at the present time as well as their application area.

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Correspondence to T. S. Tikhomirova.

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This article does not involve any studies with human participants performed by any of the authors.

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Tikhomirova, T.S., Taraskevich, M.S. & Ponomarenko, O.V. The role of laboratory-scale bioreactors at the semi-continuous and continuous microbiological and biotechnological processes. Appl Microbiol Biotechnol 102, 7293–7308 (2018). https://doi.org/10.1007/s00253-018-9194-z

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  • DOI: https://doi.org/10.1007/s00253-018-9194-z

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