Abstract.
In this report, we describe the cloning, sequencing, and expression of the bovine orthologue of CD26 (BoCD26). Several monoclonal antibodies specific for a molecule, activation molecule 3 (ACT3), aberrantly expressed on superantigen-stimulated bovine CD8+ lymphocytes, reacted with recombinant BoCD26 expressed in COS-7 and CHO cells. We also showed that human CD8+ T cells stimulated by a superantigen expressed CD26 at high levels. These results demonstrate that ACT3 is identical to BoCD26 and suggest that CD26 upregulation on CD8+ T cells is a general phenomenon of superantigens and not limited to their effects on bovine cells.
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Lee, SU., Park, YH., Davis, W.C. et al. Molecular characterization of bovine CD26 upregulated by a staphylococcal superantigen. Immunogenetics 54, 216–220 (2002). https://doi.org/10.1007/s00251-002-0456-6
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DOI: https://doi.org/10.1007/s00251-002-0456-6