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European Biophysics Journal

, Volume 48, Issue 3, pp 297–302 | Cite as

Slow relaxation during and after perturbation of bistable kinetics of gene expression

  • Vladimir P. ZhdanovEmail author
Biophysics Letter
  • 42 Downloads

Abstract

After a short perturbation of a bistable genetic network, it returns to its initial steady state or transits to another steady state. The time scale characterizing such transient regimes can be appreciably longer compared to those of the degradation of the perturbed mRNAs and proteins. The author shows in detail the specifics of this slowdown of the transient kinetics using mean-field kinetic equations and Monte Carlo simulations. Attention is focused on nanocarrier-mediated delivery and release of short non-coding RNA (e.g., miRNA or siRNA) into cells with subsequent suppression of the populations of the targeted mRNA and corresponding protein.

Keywords

Bistability Transient kinetics Gene expression Mean-field kinetic equations Monte Carlo simulations Drug delivery 

Notes

Acknowledgements

This work was supported by (1) Swedish Foundation for Strategic Research (Project No IRC15-0065) and (2) Russian Academy of Sciences and Federal Agency for Scientific Organizations (project 0303-2016-0001).

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Copyright information

© European Biophysical Societies' Association 2019

Authors and Affiliations

  1. 1.Section of Biological Physics, Department of PhysicsChalmers University of TechnologyGöteborgSweden
  2. 2.Boreskov Institute of Catalysis, Russian Academy of SciencesNovosibirskRussia

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