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Microbial Ecology

, Volume 78, Issue 1, pp 6–19 | Cite as

Adaptation to Fasting in Crucian Carp (Carassius auratus): Gut Microbiota and Its Correlative Relationship with Immune Function

  • Tongtong Li
  • Mengting Qi
  • François-Joël Gatesoupe
  • Dongcan Tian
  • Weihua Jin
  • Jun Li
  • Qiang Lin
  • Shijin WuEmail author
  • Huan LiEmail author
Microbiology of Aquatic Systems

Abstract

Fasting influences the overall physiology of fish, and the knowledge how the gut microbiota, growth performances, and immune function in response to intermittent and long-term fasting is still insufficient. Here, we characterized the effects of fasting on the host-gut microbiota in crucian carp, which would enhance our insight into physiological adaptation to fasting. To achieve this, we investigated the gut microbial communities of crucian carp with different fasting stress, and corresponding immune and growth parameters. The gut microbial communities were structured into four clusters according to different fasting stress, namely one control group (feed regularly), two intermittent fasting groups (fasting period and re-feeding period, respectively), and one long-term fasting group. Intermittent fasting significantly improved the activity of superoxide dismutase (SOD) and lysozyme (LZM) (ANOVA, p < 0.05) and significantly increased alpha diversity and ecosystem stability of gut microbiota (ANOVA, p < 0.05). Gut length (GL) and condition factor (CF) showed no significant difference between the control group (CG) and intermittent fasting group under re-feeding period (RIF) (ANOVA, p = 0.11), but relative gut length (RGL) in group RIF was higher than that in the CG (ANOVA, p = 0.00). The bacterial genera Bacteroides, Akkermansia, and Erysipelotrichaceae were enriched in fishes under intermittent fasting. Two Bacteroides OTUs (OTU50 and OTU1292) correlated positively with immune (SOD, complement, and LZM) and growth (GL and RGL) parameters. These results highlight the possible interplay between growth performances, immune function, and gut microbiota in response to fasting.

Keywords

Fasting Gut microbiota Crucian carp Growth performance Immune function 

Notes

Author Contributions

TL, HL, and SW designed the experiments in this study. TL and MQ performed the experiments. TL, HL, and MQ wrote the original manuscript. TL, HL, FJG, MQ, DT, JL, WJ, and SW edited the manuscript. MQ, QL, and HL contributed to the sampling and data analysis pipeline. All authors contributed to the revision of this manuscript.

Funding Information

The authors thank the support by the Fundamental Research Funds for the Central Universities (lzujbky-2018-68), Zhejiang Provincial Natural Science Foundation of China (LY18E090010), National Natural Science Foundation of China (41506165), and China Postdoctoral Science Foundation (2017M621965).

Compliance with Ethical Standards

Conflict of Interest

The authors declare that they have no competing interests.

Supplementary material

248_2018_1275_MOESM1_ESM.pdf (327 kb)
ESM 1 (PDF 326 kb)

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Copyright information

© Springer Science+Business Media, LLC, part of Springer Nature 2018

Authors and Affiliations

  • Tongtong Li
    • 1
  • Mengting Qi
    • 1
  • François-Joël Gatesoupe
    • 2
  • Dongcan Tian
    • 1
  • Weihua Jin
    • 1
  • Jun Li
    • 1
  • Qiang Lin
    • 3
  • Shijin Wu
    • 1
    Email author
  • Huan Li
    • 4
    Email author
  1. 1.Department of Applied Biology, College of Biotechnology and BioengineeringZhejiang University of TechnologyHangzhouChina
  2. 2.NUMEA, INRAUniversity of Pau and Pays AdourSaint Pée sur NivelleFrance
  3. 3.Key Laboratory of Environmental and Applied Microbiology, CAS; Environmental Microbiology Key Laboratory of Sichuan Province, Chengdu Institute of BiologyChinese Academy of SciencesChengduChina
  4. 4.Institute of Occupational Health and Environmental Health, School of Public HealthLanzhou UniversityLanzhouChina

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