Abstract.
Background:
Persistent hyperinsulinemic hypoglycaemia of infancy (PHHI) is often resistant to medical therapy. Surgery is therefore necessary. It is due to focal adenomatous islet-cell hyperplasia treatable by partial pancreatectomy, or diffuse beta-cell hyperfunction, which requires near-total pancreatectomy. Pancreatic venous sampling (PVS) is the reference technique for the preoperative diagnosis and localization of focal forms of PHHI in the pancreas. However, hypoglycaemia is necessary to analyse the results and PVS is technically challenging. Pancreatic arterial calcium stimulation (PACS) is technically easier and does not require hypoglycaemia.
Aim:
To study the accuracy in the diagnosis and localization of PHHI.
Materials and methods:
PACS was performed in 12 patients and correlated with histology.
Results:
The accuracy of PACS is poor in diffuse lesions since only two of six cases were correctly identified by this test. Five of six focal lesions were correctly recognized and located.
Conclusions:
PACS is less accurate than PVS in PHHI. Currently, it should be performed only when PVS fails.
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Received: 15 December 2000 Accepted: 6 March 2001
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Chigot, V., De Lonlay, P., Nassogne, MC. et al. Pancreatic arterial calcium stimulation in the diagnosis and localisation of persistent hyperinsulinemic hypoglycaemia of infancy. Pediatric Radiology 31, 650–655 (2001). https://doi.org/10.1007/s002470100522
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DOI: https://doi.org/10.1007/s002470100522