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Herpes simplex encephalitis: MRI findings in two cases confirmed by polymerase chain reaction assay

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Abstract.

Herpes simplex virus (HSV) type I causes a fulminant necrotising meningoencephalitis distinguished from other encephalitides by its focal and often haemorrhagic nature. Specific antiviral therapy with acyclovir can significantly improve the prognosis. We present MRI findings of two cases of herpes simplex encephalitis (HSE) confirmed by PCR analysis, focusing on the serial changes after acyclovir therapy: gyral swelling, high signal intensity on T2-weighted images in the subfrontal region, temporal lobe and insula in the initial stage, then regional extension with enhancement and haemorrhage despite appropriate acyclovir therapy, and finally encephalomalacia and brain atrophy.

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Authors and Affiliations

  1. Department of Radiology and the Institute of Radiation Medicine, Seoul National University Hospital, 28 Yongon-dong, Chongno-gu, Seoul 110–744, Korea, , , , , , KR

    Joon Woo Lee, I.-O. Kim, W. S. Kim & Kyung Mo Yeon

  2. Department of Paediatrics, Seoul National University College of Medicine, Seoul, Korea, , , , , , KR

    Hoan-Jong Lee & Yong Seung Hwang

Authors
  1. Joon Woo Lee
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  2. I.-O. Kim
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  3. W. S. Kim
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  4. Kyung Mo Yeon
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  5. Hoan-Jong Lee
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  6. Yong Seung Hwang
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Received: 3 October 2000 Accepted: 20 March 2001

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Lee, J., Kim, IO., Kim, W. et al. Herpes simplex encephalitis: MRI findings in two cases confirmed by polymerase chain reaction assay. Pediatric Radiology 31, 619–623 (2001). https://doi.org/10.1007/s002470100508

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  • DOI: https://doi.org/10.1007/s002470100508

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