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Pediatric Radiology

, Volume 30, Issue 6, pp 386–393 | Cite as

Hepatic regenerating nodules: a mimic of recurrent cancer in children

  • H. Brisse
  • V. Servois
  • B. Bouche
  • F. Avni
  • P. Petit
  • F. Thibault
  • J. -M. Zucker
  • C. Devalck
  • S. Neuenschwander
Original article

Abstract

Background. Pseudometastatic lesions of the liver may be discovered incidentally in children previously treated for malignant tumour.¶Objective. To describe the radiological pattern of these lesions and to analyse their pathogenesis.¶Materials and methods. Nine children, 2–12 years' old at the time of diagnosis, are described in this retrospective multicentre report. The primary tumours were: nephroblastoma (n = 2), neuroblastoma (n = 2), Ewing's tumour/PNET (n = 2), non-Hodgkin's lymphoma (n = 1), and osteosarcoma (n = 2), treated by surgery (8/9), chemotherapy (9/9), intensive chemotherapy and bone-marrow transplantation (5/9), and radiotherapy (7/9). Three children suffered veno-occlusive disease (VOD) during treatment. The hepatic assessment was performed by sonography (8/9), Doppler (7/9), multiphase spiral CT (8/9) and MRI (7/9).¶Results. Lesions were discovered 15 months to 16 years after completing treatment. CT was the most sensitive modality for diagnosis. Lesions were multiple in eight cases, measured 2–50 mm, and appeared hypervascular on the arterial phase of CT and/or MRI in every case. Metastases were excluded on the basis of histological verification (n = 2) and clinical and radiological follow-up.¶Conclusion. Pseudometastatic hypervascular hepatic nodules can appear after treatment of a malignant tumour in children. The hypothesis of benign regenerative lesions secondary to treatment and/or VOD is considered.

Keywords

Nodule Lymphoma Malignant Tumour Osteosarcoma Neuroblastoma 
These keywords were added by machine and not by the authors. This process is experimental and the keywords may be updated as the learning algorithm improves.

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Copyright information

© Springer-Verlag Berlin Heidelberg 2000

Authors and Affiliations

  • H. Brisse
    • 1
  • V. Servois
    • 1
  • B. Bouche
    • 2
  • F. Avni
    • 2
  • P. Petit
    • 3
  • F. Thibault
    • 1
  • J. -M. Zucker
    • 4
  • C. Devalck
    • 5
  • S. Neuenschwander
    • 1
  1. 1.Department of Radiology, Institut Curie, 26 rue d'Ulm, 75 005 Paris, FranceFR
  2. 2.Department of Radiology, HUDERF, Brussels, BelgiumBE
  3. 3.Department of Radiology, Hôpital d'Enfants de la Timone, Marseille, FranceFR
  4. 4.Department of Paediatric Oncology, Institut Curie, Paris, FranceFR
  5. 5.Department of Paediatric Oncology, HUDERF, Brussels, BelgiumBE

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