Abstract
Background. Iodixanol (Visipaque, Nycomed Imaging AS, Oslo, Norway) is a new non-ionic and isotonic X-ray contrast medium. Objective. To assess its safety and efficacy for paediatric excretory urography. Materials and methods. A three-centre trial in which 72 patients were randomised into three parallel groups: iodixanol 270 mgI/ml, iodixanol 320 mgI/ml and iohexol 300 mgI/ml (Omnipaque, Nycomed Imaging, Oslo, Norway). Doses ranging from 1 to 3 ml/kg never exceeded 50 ml. Pulse rate and blood pressure were recorded before, during, and after the examination. Adverse events, including injection associated discomfort, were recorded during and up to 24 h after the examination. The diagnostic quality of the urograms was assessed on a four-level scale. Results. No serious adverse event occurred in any of the three groups. One patient who was given iodixanol 270 mgI/ml, three who received iodixanol 320 mgI/ml, and one who received iohexol 300 mgI/ml experienced transient adverse events. More than 80 % of the urograms in all three groups were rated “good” or “excellent”. Conclusion. Iodixanol, either 270 mgI/ml or 320 mgI/ml, is well tolerated and efficacious for excretory urography in children.
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Received: 22 March 1997 Accepted: 5 August 1997
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Dacher, JN., Sirinelli, D., Boscq, M. et al. Iodixanol in paediatric excretory urography: efficiency and safety compared to iohexol. Pediatric Radiology 28, 112–114 (1998). https://doi.org/10.1007/s002470050307
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DOI: https://doi.org/10.1007/s002470050307