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Magnetic resonance imaging with fluid-attenuated inversion recovery pulse sequences in MELAS syndrome

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Abstract

We report the brain magnetic resonance imaging findings in the case of a 5-year-old boy with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes (MELAS). Fluid-attenuation inversion recovery (FLAIR) imaging revealed multifocal abnormal cortical signals which were difficult to see on conventional T1- and T2-weighted images. Although the patient was in an advanced clinical stage of disease and had severe cortical atrophy, FLAIR imaging demonstrated characteristic findings of MELAS.

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References

  1. Pavlakis SG, Phillips PC, DiMauro S, De Vivo DC, Rowland LP (1984) Mitochondrial myopathy, encephalopathy, lactic acidosis and strokelike episodes: a distinctive clinical syndrome. Ann Neurol 16: 481

    Article  PubMed  CAS  Google Scholar 

  2. Hajnal JV, Bryant DJ, Kasuboski L, Pattany PM, De Coene B, Lewis PD, Pennock JM, Oatridge A, Young IR, Bydder GM (1992) Use of fluid attenuated inversion recovery (FLAIR) pulse sequences in MRI of the brain. J Comput Assist Tomogr 16: 841

    Article  PubMed  CAS  Google Scholar 

  3. Hasegawa H, Matsuoka T, Goto Y, Nonaka I (1991) Strongly succinate dehydrogenase-reactive blood vessels in muscles from patients with mitochondrial myopathy, encephalopathy, lactic acidosis and stroke-like episodes. Ann Neurol 29: 601

    Article  PubMed  CAS  Google Scholar 

  4. Matthews PM, Tampieri D, Berkovic SF, Andermann F, Silver K, Chitya D, Arnold DL (1991) Magnetic resonance imaging shows specific abnormalities in the MELAS syndrome. Neurology 41: 1043

    PubMed  CAS  Google Scholar 

  5. Ohama E, Ohara S, Ikuta F, Tanaka K, Nishizawa M, Miyatake T (1987) Mitochondrial angiopathy in cerebral blood vessels of mitochondrial encephalomyopathy. Acta Neuropathol (Berl) 74: 226

    Article  CAS  Google Scholar 

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Authors and Affiliations

  1. Department of Pediatrics, Shimane Medical University, 89-1 Enya, Izumo, 693, Shimane, Japan

    Masahiko Kimura, Yuki Hasegawa, Kenji Yasuda, Hitoshi Sejima, Makoto Inoue & Seiji Yamaguchi

  2. Department of Pediatrics, Masuda Red Cross Hospital, Masuda, Shimane, Japan

    Yukinori Ando

  3. Department of Child Neurology, Okayama University, School of Medicine, Okayama, Japan

    Shigeru Ohno

Authors
  1. Masahiko Kimura
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  2. Yuki Hasegawa
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  3. Kenji Yasuda
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  4. Hitoshi Sejima
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  5. Makoto Inoue
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  6. Seiji Yamaguchi
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  7. Yukinori Ando
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  8. Shigeru Ohno
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Kimura, M., Hasegawa, Y., Yasuda, K. et al. Magnetic resonance imaging with fluid-attenuated inversion recovery pulse sequences in MELAS syndrome. Pediatr Radiol 27, 153–154 (1997). https://doi.org/10.1007/s002470050089

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  • DOI: https://doi.org/10.1007/s002470050089

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