Abstract
Background
The normal values of optic nerve diameter and optic nerve sheath diameter might be beneficial in defining an abnormality such as optic nerve hypoplasia, or enlarged subarachnoid space, reflecting the state of increased intracranial pressure.
Objective
To study the normal optic nerve diameter and optic nerve sheath diameter on magnetic resonance imaging (MRI) in the early years of postnatal visual development from MRI of the brain.
Materials and methods
MRI of the brain in patients ages 4 years and younger were gathered. Forty-two studies with normal intracranial findings and a lack of history of increased intracranial pressure were retrospectively reviewed by two reviewers using axial T2-weighted images. Measurements were performed in transverse diameter perpendicular to the optic nerve at 3 mm behind the globe.
Results
The mean optic nerve diameter of the 77 optic nerves were 2.5 mm (95% confidence interval [CI] 2.4–2.6). The mean optic nerve sheath diameter values of the 79 optic nerve sheath complexes were 5.0 mm (95% CI 4.9–5.1). The mean±standard deviation optic nerve diameter and optic nerve sheath diameter stratified by each age groups were, respectively, 0 to <1 year: 2.3±0.40 and 4.81±0.37; 1 to <2 years: 2.6±0.2 and 5.0±0.4; 2 to <3 years: 2.4±0.3 and 4.9±0.6, and 3 to <4 years: 2.9±0.4 and 5.2±0.60 mm.
Conclusion
Seventy-four of the 77 measurements (96%) were of the measurements were above the threshold of 2 mm for optic nerve diameter. Seventy-seven of the 79 measurements (97%) were of the measurements were below the threshold of 6 mm for optic nerve sheath diameter.
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References
Magoon EH, Robb RM (1981) Development of myelin in human optic nerve and tract. A light and electron microscopic study. Arch Ophthalmol 99:655–659
Hellström A, Wiklund L-M, Svensson E (1999) Diagnostic value of magnetic resonance imaging and planimetric measurement of optic disc size in confirming optic nerve hypoplasia. J AAPOS 3:104–108
Lenhart PD, Desai NK, Bruce BB et al (2014) The role of magnetic resonance imaging in diagnosing optic nerve hypoplasia. Am J Ophthalmol 158:1164–1171 e2
Rosenberg JB, Shiloh AL, Savel RH, Eisen LA (2011) Non-invasive methods of estimating intracranial pressure. Neurocrit Care 15:599–608
Rothfus WE, Curtin HD, Slamovits TL, Kennerdell JS (1984) Optic nerve/sheath enlargement. A differential approach based on high-resolution CT morphology. Radiology 150:409–415
Helmke K, Hansen HC (1996) Fundamentals of transorbital sonographic evaluation of optic nerve sheath expansion under intracranial hypertension II. Patient study. Pediatr Radiol 26:706–710
Helmke K, Hansen HC (1996) Fundamentals of transorbital sonographic evaluation of optic nerve sheath expansion under intracranial hypertension. I. Experimental study. Pediatr Radiol 26:701–705
Steinborn M, Friedmann M, Hahn H et al (2015) Normal values for transbulbar sonography and magnetic resonance imaging of the optic nerve sheath diameter (optic nerve sheath diameter) in children and adolescents. Ultraschall Med 36:54–58
Shofty B, Ben-Sira L, Constantini S et al (2012) Optic nerve sheath diameter on MR imaging: establishment of norms and comparison of pediatric patients with idiopathic intracranial hypertension with healthy controls. AJNR Am J Neuroradiol 33:366–369
Al-Haddad CE, Sebaaly MG, Tutunji RN et al (2018) Optic nerve measurement on MRI in the pediatric population: normative values and correlations. AJNR Am J Neuroradiol 39:369–374
Bre’mond-Gignaca D, Copin H, Lapillonn A et al (2011) Visual development in infants: physiological and pathological mechanisms. Curr Opin Ophthalmol 22(Suppl):S1–S8
Salmela MB, Cauley KA, Andrews T et al (2009) Magnetic resonance diffusion tensor imaging of the optic nerves to guide treatment of pediatric suprasellar tumors. Pediatr Neurosurg 45:467–471
Cauley KA, Filippi CG (2013) Diffusion-tensor imaging of small nerve bundles: cranial nerves, peripheral nerves, distal spinal cord, and lumbar nerve roots--clinical applications. AJR Am J Roentgenol 201:W326–W335
Filippi CG, Bos A, Nickerson JP et al (2012) Magnetic resonance diffusion tensor imaging (MRDTI) of the optic nerve and optic radiations at 3T in children with neurofibromatosis type I (NF-1). Pediatr Radiol 42:168–174
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Janthanimi, P., Dumrongpisutikul, N. Pediatric optic nerve and optic nerve sheath diameter on magnetic resonance imaging. Pediatr Radiol 49, 1071–1077 (2019). https://doi.org/10.1007/s00247-019-04404-6
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DOI: https://doi.org/10.1007/s00247-019-04404-6