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Ultrafast pediatric chest computed tomography: comparison of free-breathing vs. breath-hold imaging with and without anesthesia in young children

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Abstract

Background

General anesthesia (GA) or sedation has been used to obtain good-quality motion-free breath-hold chest CT scans in young children; however pulmonary atelectasis is a common and problematic accompaniment that can confound diagnostic utility. Dual-source multidetector CT permits ultrafast high-pitch sub-second examinations, minimizing motion artifact and potentially eliminating the need for a breath-hold.

Objective

The purpose of this study was to evaluate the feasibility of free-breathing ultrafast pediatric chest CT without GA and to compare it with breath-hold and non-breath-hold CT with GA.

Materials and methods

Young (≤3 years old) pediatric outpatients scheduled for chest CT under GA were recruited into the study and scanned using one of three protocols: GA with intubation, lung recruitment and breath-hold; GA without breath-hold; and free-breathing CT without anesthesia. In all three protocols an ultrafast high-pitch CT technique was used. We evaluated CT images for overall image quality, presence of atelectasis and motion artifacts.

Results

We included 101 scans in the study. However the GA non-breath-hold technique was discontinued after 15 scans, when it became clear that atelectasis was a major issue despite diligent attempts to mitigate it. This technique was therefore not included in statistical evaluation (86 remaining patients). Overall image quality was higher (P=0.001) and motion artifacts were fewer (P<.001) for scans using the GA with intubation and recruitment technique compared to scans in the non-GA free-breathing group. However no significant differences were observed regarding the presence of atelectasis between these groups.

Conclusion

We demonstrated that although overall image quality was best and motion artifact least with a GA-breath-hold intubation and recruitment technique, free-breathing ultrafast pediatric chest CT without anesthesia provides sufficient image quality for diagnostic purposes and can be successfully performed both without and with contrast agent in young infants.

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Authors and Affiliations

  1. Department of Radiology, Lucile Packard Children’s Hospital at Stanford University, 725 Welch Road, Room 1677 MC 5913, Stanford, CA, 94304, USA

    Aya Kino, Evan J. Zucker, Jerry Kneebone, Frandics Chan & Beverley Newman

  2. Department of Anesthesia, Lucile Packard Children’s Hospital at Stanford University, Stanford, CA, USA

    Anita Honkanen

  3. Environmental Health and Safety, Stanford University, Stanford, CA, USA

    Jia Wang

Authors
  1. Aya Kino
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  2. Evan J. Zucker
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  3. Anita Honkanen
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  4. Jerry Kneebone
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  5. Jia Wang
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  6. Frandics Chan
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  7. Beverley Newman
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Correspondence to Aya Kino.

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Kino, A., Zucker, E.J., Honkanen, A. et al. Ultrafast pediatric chest computed tomography: comparison of free-breathing vs. breath-hold imaging with and without anesthesia in young children. Pediatr Radiol 49, 301–307 (2019). https://doi.org/10.1007/s00247-018-4295-5

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  • DOI: https://doi.org/10.1007/s00247-018-4295-5

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