Reversible lesions of the splenium of the corpus callosum in children — additional evidence from a Caucasian population
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Le Bras and colleagues  recently reported an interesting case series describing seven children with reversible splenial lesion of the corpus callosum. Reversible splenial lesion syndrome is a recently introduced nosologic entity with a variety of clinical manifestations and of different aetiologies . Possible causes include seizures, antiepileptic drugs withdrawal, infections, altered metabolic states such as hypoglycemia and hypernatremia and other associated clinical conditions such as X-linked Charcot-Marie-Tooth disease [1, 2, 3]. Clinical symptoms vary from altered consciousness (confusion, lethargy, delirium) to seizures or focal neurologic symptoms that are usually unrelated to the splenial lesion. MRI findings also vary from a single ovoid lesion centred in the splenium of corpus callosum with diffusion restriction (also referred to as mild encephalopathy/encephalitis with reversible splenial lesion type 1) to more diffuse involvement of corpus callosum and...
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- 1.Le Bras A, Proisy M, Kuchenbuch M et al (2018) Reversible lesions of the corpus callosum with initially restricted diffusion in a series of Caucasian children. Pediatr Radiol. https://doi.org/10.1007/s00247-018-4124-x