Pediatric Radiology

, Volume 48, Issue 7, pp 1035–1037 | Cite as

Reversible lesions of the splenium of the corpus callosum in children — additional evidence from a Caucasian population

  • Maria Camilla Rossi Espagnet
  • Andrea Romano
  • Daniela Longo
  • Lorenzo Figà-Talamanca
Letter to the Editor

Dear Editors,

Le Bras and colleagues [1] recently reported an interesting case series describing seven children with reversible splenial lesion of the corpus callosum. Reversible splenial lesion syndrome is a recently introduced nosologic entity with a variety of clinical manifestations and of different aetiologies [2]. Possible causes include seizures, antiepileptic drugs withdrawal, infections, altered metabolic states such as hypoglycemia and hypernatremia and other associated clinical conditions such as X-linked Charcot-Marie-Tooth disease [1, 2, 3]. Clinical symptoms vary from altered consciousness (confusion, lethargy, delirium) to seizures or focal neurologic symptoms that are usually unrelated to the splenial lesion. MRI findings also vary from a single ovoid lesion centred in the splenium of corpus callosum with diffusion restriction (also referred to as mild encephalopathy/encephalitis with reversible splenial lesion type 1) to more diffuse involvement of corpus callosum and...


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Conflicts of interest



  1. 1.
    Le Bras A, Proisy M, Kuchenbuch M et al (2018) Reversible lesions of the corpus callosum with initially restricted diffusion in a series of Caucasian children. Pediatr Radiol.
  2. 2.
    Garcia-Monco JC, Cortina IE, Ferreira E et al (2011) Reversible splenial lesion syndrome (RESLES): what’s in a name? J Neuroimaging 21:e1–e14CrossRefGoogle Scholar
  3. 3.
    Kontzialis M, Soares BP, Huisman T (2017) Lesions in the splenium of the corpus callosum on MRI in children: a review. J Neuroimaging 27:549–561CrossRefPubMedGoogle Scholar
  4. 4.
    Ka A, Britton P, Troedson C et al (2015) Mild encephalopathy with reversible splenial lesion: an important differential of encephalitis. Eur J Paediatr Neurol 19:377–382CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  1. 1.Neuroradiology Unit, Imaging Department,Bambino Gesù Children’s Hospital,RomeItaly
  2. 2.Neuroradiology Unit, NESMOS Department,Sapienza University,RomeItaly
  3. 3.Department of Odontostomatological and Maxillo-Facial Sciences,Sapienza University,RomeItaly

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