Pediatric Radiology

, Volume 48, Issue 5, pp 638–647 | Cite as

Can diffusion-weighted whole-body MRI replace contrast-enhanced CT for initial staging of Hodgkin lymphoma in children and adolescents?

  • Rodrigo Regacini
  • Andrea Puchnick
  • Flavio Augusto Vercillo Luisi
  • Henrique Manoel Lederman
Original Article



Although positron emission tomography with 18F–fluoro-2-deoxyglucose (FDG-PET/CT) has been recommended as the method of choice for lymphoma staging, it has limited availability in several countries, therefore, studies comparing whole-body magnetic resonance imaging (MRI) to conventional staging methods or to FDG-PET/CT are an important tool to establish whole-body MRI as an alternative to these methods.


To compare whole-body MRI versus conventional imaging methods for staging of Hodgkin lymphoma in children and adolescents.

Materials and methods

The study included 22 patients ages 5 to 21 years. Staging was performed using conventional imaging methods and whole-body MRI. Conventional imaging methods were defined as computed tomography (CT) of the neck, chest, abdomen and pelvis and ultrasonography of the neck and/or abdomen. We calculated the sensitivity of these methods for Hodgkin lymphoma staging and their sensitivity and specificity for detecting sites of nodal and extranodal involvement.


The sensitivity of whole-body MRI for Hodgkin lymphoma staging was superior to that of conventional imaging methods (95.5% vs. 86.4%, respectively), but both methods had similar sensitivity and specificity for detecting involvement of nodal sites (99.1% and 100% vs. 97.3% and 100%, respectively) and extranodal sites (90.5% and 98.7% vs. 90.5% and 99.4%, respectively).


Whole-body MRI has excellent sensitivity for staging of Hodgkin lymphoma in children and adolescents. It can thus be considered an alternative for this purpose, particularly because it does not expose patients to ionizing radiation.


Children Computed tomography Diffusion-weighted imaging Hodgkin lymphoma Magnetic resonance imaging Whole-body imaging 


Compliance with ethical standards

Conflicts of interest



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Copyright information

© Springer-Verlag GmbH Germany, part of Springer Nature 2018

Authors and Affiliations

  • Rodrigo Regacini
    • 1
  • Andrea Puchnick
    • 2
  • Flavio Augusto Vercillo Luisi
    • 3
  • Henrique Manoel Lederman
    • 1
  1. 1.Department of Diagnostic Imaging, Escola Paulista de MedicinaUniversidade Federal de São Paulo (UNIFESP)São PauloBrazil
  2. 2.Department of Diagnostic Imaging, Educational and Research Support, Escola Paulista de MedicinaUniversidade Federal de São Paulo (UNIFESP)São PauloBrazil
  3. 3.Department of Pediatrics, Division of Oncology, Escola Paulista de MedicinaUniversidade Federal de São Paulo (UNIFESP)São PauloBrazil

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