Pediatric Radiology

, Volume 47, Issue 12, pp 1688–1689 | Cite as

Interpreting signal-intensity ratios without visible T1 hyperintensities in clinical gadolinium retention studies

Letter to the Editor


Compliance with ethical standards

Conflicts of interest

A. Radbruch has consultancy agreements with, has received honoraria for talks and advisory board membership from, and has received research funding from Bayer HeathCare and Guerbet Laboratories. C.C. Quattrocchi has received lecture honoraria from Bayer HealthCare.


  1. 1.
    Rossi Espagnet MC, Bernardi B, Pasquini L et al (2017) Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children. Pediatr Radiol.
  2. 2.
    Flood TF, Stence NV, Maloney JA, Mirsky DM (2017) Pediatric brain: repeated exposure to linear gadolinium-based contrast material is associated with increased signal intensity at unenhanced T1-weighted MR imaging. Radiology 282:222–228CrossRefPubMedGoogle Scholar
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    Roberts DR, Chatterjee AR, Yazdani M et al (2016) Pediatric patients demonstrate progressive T1-weighted hyperintensity in the dentate nucleus following multiple doses of gadolinium-based contrast agent. AJNR Am J Neuroradiol 37:2340–2347CrossRefPubMedPubMedCentralGoogle Scholar
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    Hu HH, Pokorney A, Towbin RB, Miller JH (2016) Increased signal intensities in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: evidence in children undergoing multiple gadolinium MRI exams. Pediatr Radiol 46:1590–1598CrossRefPubMedGoogle Scholar
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    Radbruch A, Haase R, Kickingereder P et al (2017) Pediatric brain: no increased signal intensity in the dentate nucleus on unenhanced T1-weighted MR images after consecutive exposure to a macrocyclic gadolinium-based contrast agent. Radiology 283:828–836CrossRefPubMedGoogle Scholar
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    Frenzel T, Apte C, Jost G et al (2017) Quantification and assessment of the chemical form of residual gadolinium in the brain after repeated administration of gadolinium-based contrast agents: comparative study in rats. Investig Radiol 52:396–404CrossRefGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Alexander Radbruch
    • 1
    • 2
  • Carlo Cosimo Quattrocchi
    • 3
  1. 1.Department of RadiologyGerman Cancer Research Center (DKFZ)HeidelbergGermany
  2. 2.Department of Diagnostic and Interventional Radiology and NeuroradiologyUniversity Hospital Essen, University Duisburg-EssenEssenGermany
  3. 3.Departmental Faculty of Medicine and SurgeryUniversità Campus Bio-Medico di RomaRomeItaly

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