Pediatric Radiology

, Volume 47, Issue 13, pp 1759–1765 | Cite as

HRCT findings of childhood follicular bronchiolitis

  • Jason P. WeinmanEmail author
  • David A. Manning
  • Deborah R. Liptzin
  • Amanda J. Krausert
  • Lorna P. Browne
Original Article



Follicular bronchiolitis is a lymphoproliferative form of interstitial lung disease (ILD) defined by the presence of peribronchial lymphoid follicles. Follicular bronchiolitis has been associated with viral infection, autoimmune disease and immunodeficiency. The most common clinical manifestation is respiratory distress in infancy followed by a prolonged course with gradual improvement. We found no reports of systematic review of high-resolution computed tomography (HRCT) findings in pediatric follicular bronchiolitis.


The purpose of this study was to describe the HRCT findings of follicular bronchiolitis in children and correlate these imaging findings with histopathology.

Materials and methods

A 5-year retrospective review of all pathology-proven cases of follicular bronchiolitis was performed. Inclusion criteria were age <18 years and an HRCT within 6 months of lung biopsy. HRCTs were reviewed by three observers and scored using the system previously described by Brody et al.


Six patients met the inclusion criteria with age range at HRCT of 7–82 months (median: 39.5 months). Pulmonary nodules (n=6) were the most common HRCT finding followed by focal consolidation (n=5), bronchiectasis (n=4) and lymphadenopathy (n=3). Tree and bud opacities and nodules on CT correlated with interstitial lymphocytic infiltrates and discrete lymphoid follicles on pathology.


The salient HRCT findings of childhood follicular bronchiolitis are bilateral, lower lung zone predominant pulmonary nodules and bronchiectasis with infantile onset of symptoms. These characteristic HRCT findings help differentiate follicular bronchiolitis from other forms of infantile onset ILD.


Bronchiectasis Chest Children Computed tomography Follicular bronchiolitis Interstitial lung disease Lung Nodule 


Compliance with ethical standards

Conflicts of Interest



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Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  • Jason P. Weinman
    • 1
    Email author
  • David A. Manning
    • 2
  • Deborah R. Liptzin
    • 3
  • Amanda J. Krausert
    • 4
  • Lorna P. Browne
    • 1
  1. 1.Department of RadiologyChildren’s Hospital ColoradoAuroraUSA
  2. 2.Department of RadiologyChildren’s Hospital of New OrleansNew OrleansUSA
  3. 3.Department of Pediatrics, Section of Pediatric PulmonologyChildren’s Hospital ColoradoAuroraUSA
  4. 4.New Orleans Forensic CenterNew OrleansUSA

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