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Pediatric Radiology

, Volume 47, Issue 12, pp 1694–1696 | Cite as

Reply to Lancelot et al.: ‘Lack of evidence of a relationship between magnetic resonance signal intensity changes in the globus pallidus and dentate nucleus, and repeated administrations of gadoterate meglumine in children’

  • Maria Camilla Rossi Espagnet
  • Paolo Tomà
  • Antonio Napolitano
Letter to the Editor

Notes

Compliance with ethical standards

Conflicts of interest

None

References

  1. 1.
    Lancelot E, Raynaud J-S, Desché P (2017) Lack of evidence of a relationship between magnetic resonance signal intensity changes in the globus pallidus and dentate nucleus, and repeated administrations of gadoterate meglumine in children. Pediatri Radiol.  https://doi.org/10.1007/s00247-017-3947-1
  2. 2.
    Rossi Espagnet CA, Bernardi B, Pasquini L et al (2017) Signal intensity at unenhanced T1-weighted magnetic resonance in the globus pallidus and dentate nucleus after serial administrations of a macrocyclic gadolinium-based contrast agent in children. Pediatr Radiol 47:633–648CrossRefPubMedGoogle Scholar
  3. 3.
    Murata N, Gonzalez-Cuyar LF, Murata K et al (2016) Macrocyclic and other non-group 1 gadolinium contrast agents deposit low levels of gadolinium in brain and bone tissue: preliminary results from 9 patients with normal renal function. Investig Radiol 51:447–453CrossRefGoogle Scholar
  4. 4.
    Ramalho J, Semelka R, AlObaidy M et al (2016) Signal intensity change on unenhanced T1-weighted images of the dentate nucleus following gadobenate dimeglumine in patients with and without previous multiple administrations of gadodiamide. Eur Radiol 26:4080–4088CrossRefPubMedGoogle Scholar
  5. 5.
    Weberling LD, Kieslich PJ, Kickingereder P et al (2016) Increased signal intensity in the dentate nucleus on unenhanced T1-weighted images after gadobenate dimeglumine administration. Investig Radiol 50:743–748CrossRefGoogle Scholar
  6. 6.
    Radbruch A, Weberling LD, Kieslich PJ et al (2016) High-signal intensity in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: evaluation of the macrocyclic gadolinium-based contrast agent gadobutrol. Investig Radiol 50:805–810CrossRefGoogle Scholar
  7. 7.
    Radbruch A, Weberling LD, Kieslich PJ et al (2016) Gadolinium retention in the dentate nucleus and globus pallidus is dependent on the class of contrast agent. Radiology 275:783–791CrossRefGoogle Scholar
  8. 8.
    Radbruch A, Haase R, Kickingereder P et al (2017) Pediatric brain: no increased signal intensity in the dentate nucleus on unenhanced T1-weighted MR images after consecutive exposure to a macrocyclic gadolinium-based contrast agent. Radiology 283:828–836CrossRefPubMedGoogle Scholar
  9. 9.
    Hu HH, Pokorney A, Towbin RB et al (2016) Increased signal intensities in the dentate nucleus and globus pallidus on unenhanced T1-weighted images: evidence in children undergoing multiple gadolinium MRI exams. Pediatr Radiol 46:1590–1598CrossRefPubMedGoogle Scholar
  10. 10.
    Kahn J, Posch H, Steffen IG et al (2017) Is there long-term signal intensity increase in the central nervous system on T1-weighted images after MR imaging with the hepatospecific contrast agent gadoxetic acid? A cross-sectional study in 91 patients. Radiology 282:708–716CrossRefPubMedGoogle Scholar
  11. 11.
    Tedeschi E, Palma G, Canna A et al (2016) In vivo dentate nucleus MRI relaxometry correlates with previous administration of gadolinium-based contrast agents. Eur Radiol 26:4577–4584CrossRefPubMedGoogle Scholar
  12. 12.
    Flood TF, Stence NV, Maloney JA et al (2017) Pediatric brain: repeated exposure to linear gadolinium-based contrast material is associated with increased signal intensity at unenhanced T1-weighted MR imaging. Radiology 282:222–228CrossRefPubMedGoogle Scholar
  13. 13.
    Smith AP, Marino M, Roberts J et al (2017) Clearance of gadolinium from the brain with no pathologic effect after repeated administration of gadodiamide in healthy rats: an analytical and histologic study. Radiology 282:743–751CrossRefPubMedGoogle Scholar
  14. 14.
    Adin ME, Kleinberg L, Vaidya D et al (2015) Hyperintense dentate nuclei on T1-weighted MRI: relation to repeat gadolinium administration. AJNR Am J Neuroradiol 36:1859–1865CrossRefPubMedPubMedCentralGoogle Scholar
  15. 15.
    Ramalho J, Ramalho M, AlObaidy M et al (2016) T1 signal-intensity increase in the dentate nucleus after multiple exposures to gadodiamide: intraindividual comparison between 2 commonly used sequences. AJNR Am J Neuroradiol 37:1427–1431CrossRefPubMedGoogle Scholar
  16. 16.
    Shen Y, Goerner FL, Snyder C et al (2015) T1 relaxivities of gadolinium-based magnetic resonance contrast agents in human whole blood at 1.5, 3, and 7 T. Investig Radiol 50:330–338CrossRefGoogle Scholar
  17. 17.
    Roberts DR, Welsh CA, DP LB 2nd, Davis WC (2017) Distribution map of gadolinium deposition within the cerebellum following GBCA administration. Neurology 88:1206–1208CrossRefPubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Neuroradiology Unit, Imaging DepartmentBambino Gesù Children’s Hospital, IRCCSRomeItaly
  2. 2.Imaging DepartmentBambino Gesù Children’s HospitalRomeItaly
  3. 3.Enterprise Risk Management, Medical Physics DepartmentBambino Gesù Children’s HospitalRomeItaly

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