Pediatric Radiology

, Volume 47, Issue 12, pp 1599–1607 | Cite as

Stomach frame-count-based attenuation correction of dynamic posterior view gastric emptying scintigraphy with continuous acquisition in children

  • Xinhua Cao
  • Xiaoyin Xu
  • Laura Drubach
  • Frederic H. Fahey
Original Article

Abstract

Background

When performing dynamic gastric emptying scintigraphy with continuous acquisition in children, a single posterior view acquisition is preferred because it allows the young patient to more easily interact with a parent or technologist even though this method tends toward overestimating gastric emptying.

Objectives

The objective of our study was to develop a new attenuation correction (AC) method to improve the accuracy of the time activity curve and the measurement of residual gastric emptying from 1-h posterior images of gastric emptying scintigraphy with continuous acquisition.

Materials and methods

We developed a frame-count-based AC for gastric emptying scintigraphy from the posterior view (posterior AC method). We retrospectively reviewed 122 gastric emptying studies performed in children using conjugated posterior and anterior views, and evaluated the statistical differences between posterior only (without AC) and posterior AC using the geometric mean method as a reference standard.

Results

The residual values obtained using posterior AC were not significantly different (P=0.813) compared to those using the geometric mean while the values using the posterior only were significantly different (P<0.001) from the geometric mean.

Conclusion

The proposed method can replace the geometric mean method to estimate gastric emptying residual fraction using patient-friendly posterior view without a significant difference in 1-h gastric emptying scintigraphy with continuous acquisition.

Keywords

Attenuation correction Children Gastric emptying scintigraphy Geometric mean Posterior view 

Notes

Acknowledgements

The work of Dr. Xiaoyin Xu was supported by the National Institutes of Health grant R01LM011415.

Compliance with ethical standards

Conflicts of interest

None

References

  1. 1.
    Donohoe KJ, Maurer AH, Ziessman HA et al (2009) Procedure guideline for adult solid-meal gastric-emptying study 3.0. J Nucl Med Technol 37:196–200CrossRefPubMedGoogle Scholar
  2. 2.
    Abell TL, Camilleri M, Donohoe K et al (2008) Consensus recommendations for gastric emptying scintigraphy: a joint report of the American Neurogastroenterology and motility society and the Society of Nuclear Medicine. J Nucl Med Technol 36:44–54CrossRefPubMedGoogle Scholar
  3. 3.
    American College of Radiology (2016) ACR-SNM technical standard for diagnostic procedures using radiopharmaceuticals http://www.acr.org/~/media/ACR/Documents/PGTS/standards/Radiopharmaceuticals.pdf. Accessed 16 August 2016
  4. 4.
    Heyman S (1998) Gastric emptying in children. J Nucl Med 39:865–869PubMedGoogle Scholar
  5. 5.
    Di Lorenzo C, Piepsz A, Ham H, Cadranel S (1987) Gastric emptying with gastro-oesophageal reflux. Arch Dis Child 62:449–453CrossRefPubMedPubMedCentralGoogle Scholar
  6. 6.
    Fisher RS, Malmud LS, Roberts GS, Lobis IF (1976) Gastroesophageal (GE) scintiscanning to detect and quantitate GE reflux. Gastroenterology 70:301–308PubMedGoogle Scholar
  7. 7.
    Davies RP, Morris LL, Savage JP et al (1987) Gastroesophageal reflux: the role of imaging in the diagnosis and management. Australas Radiol 31:157–163CrossRefPubMedGoogle Scholar
  8. 8.
    Caldaro T, Garganese MC, Torroni F et al (2011) Delayed gastric emptying and typical scintigraphic gastric curves in children with gastroesophageal reflux disease: could pyloromyotomy improve this condition? J Pediatr Surg 46:863–869CrossRefPubMedGoogle Scholar
  9. 9.
    Christian PE, Moore JG, Sorenson JA et al (1980) Effects of meal size and correction technique on gastric emptying time: studies with two tracers and opposed detectors. J Nucl Med 21:883–885PubMedGoogle Scholar
  10. 10.
    Moore JG, Christian PE, Taylor AT, Alazraki N (1985) Gastric emptying measurements: delayed and complex emptying patterns without appropriate correction. J Nuc I Med 26:1206–1210Google Scholar
  11. 11.
    Ford PV, Kennedy RL, Vogel JM (1992) Comparison of left anterior oblique, anterior and geometric mean methods for determining gastric emptying times. J Nucl Med 33:127–130PubMedGoogle Scholar
  12. 12.
    Collins PJ, Horowitz M, Shearman DJ, Chatterton BE (1984) Correction for tissue attenuation in radionuclide gastric emptying studies: a comparison of a lateral image method and a geometric mean method. Br J Radiol 57:689–695CrossRefPubMedGoogle Scholar
  13. 13.
    Collins PJ, Horowitz M, Cook DJ et al (1983) Gastric emptying in normal subjects - a reproducible technique using a single scintillation camera and computer system. Gut 24:1117–1125CrossRefPubMedPubMedCentralGoogle Scholar
  14. 14.
    Drubach LA, Kourmouzi V, Cao X et al (2012) Gastric emptying in children: what is the best acquisition method? J Pediatr Gastroenterol Nutr 55:191–193CrossRefPubMedGoogle Scholar
  15. 15.
    Fahey FH, Ziessman HA, Collen MJ, Eggli DF (1989) Left anterior oblique projection and peak-to-scatter ratio for attenuation compensation of gastric emptying studies. J Nucl Med 30:233–239PubMedGoogle Scholar
  16. 16.
    Cao X, Tetrault T, Fahey FH, Treves ST (2008) Automated motion correction based on target tracking for dynamic nuclear medicine studies. Proc. SPIE 6914, Medical Imaging: Image Processing 69142B. doi: 10.1117/12.770440
  17. 17.
    Lin E, Connolly LP, Drubach LA et al (2000) Effect of early emptying on quantitation and interpretation of liquid gastric emptying studies of infants and young children. J Nucl Med 41:596–599PubMedGoogle Scholar
  18. 18.
    Griffith GH, Owen GM, Kirkman S, Shields R (1966) Measurement of the rate of gastric emptying using chromium-51. Lancet 1:1244–1245CrossRefPubMedGoogle Scholar
  19. 19.
    Camilleri M, Hasler WL, Parkman HP et al (1998) Measurement of gastroduodenal motility in the GI laboratory. Gastroenterology 115:747–762CrossRefPubMedGoogle Scholar
  20. 20.
    Heyman S (1995) Pediatric gastrointestinal motility studies. Semin Nucl Med 25:339–347CrossRefPubMedGoogle Scholar
  21. 21.
    Urbain JL, Vekemans MC, Parkman H et al (1995) Dynamic antral scintigraphy to characterize gastric antral motility in functional dyspepsia. J Nucl Med 36:1579–1586PubMedGoogle Scholar
  22. 22.
    Maurer AH (2012) Advancing gastric emptying studies: standardization and new parameters to assess gastric motility and function. Semin Nucl Med 42:101–112CrossRefPubMedGoogle Scholar
  23. 23.
    Urbain JL, Siegel JA, Charkes ND et al (1989) The two-component stomach: effects of meal particle size on fundal and antral emptying. Eur J Nucl Med 15:254–259CrossRefPubMedGoogle Scholar
  24. 24.
    Staghellini V, Tosetti C, Corinaldesi R (1997) Symptoms and gastric functions in dyspepsia--goodbye to gastroparesis or to inadequate studies? Neurogastroenterol Motil 9:203–204CrossRefGoogle Scholar
  25. 25.
    Tack J, Caenepeel P, Fischler B et al (2001) Symptoms associated with hypersensitivity to gastric distention in functional dyspepsia. Gastroenterology 121:526–535CrossRefPubMedGoogle Scholar
  26. 26.
    Piessevaux H, Tack J, Walrand S et al (2003) Intragastric distribution of a standardized meal in health and functional dyspepsia: correlation with specific symptoms. Neurogastroenterol Motil 15:447–455CrossRefPubMedGoogle Scholar
  27. 27.
    Tothill P, McLoughlin GP, Heading RC (1978) Techniques and errors in scintigraphic measurements of gastric emptying. J Nucl Med 19:256–261PubMedGoogle Scholar
  28. 28.
    Roland J, Dobbeleir A, Ham HR, Vandevivere J (1989) Continuous anterior acquisitions in gastric emptying: comparison with the mean. Clin Nucl Med 14:881–884CrossRefPubMedGoogle Scholar
  29. 29.
    VanDeventer G, Thomson J, Graham LS et al (1983) Vaildation of corrections for errors in collimation during measurement of gastric emptying of nuclide-labeled meals. J Nucl Med 24:187–196PubMedGoogle Scholar
  30. 30.
    Meyer JH, VanDeventer G, Graham LS et al (1983) Error and corrections with scintigraphic measurement of gastric emptying of solid foods. J Nucl Med 24:197–203PubMedGoogle Scholar

Copyright information

© Springer-Verlag GmbH Germany 2017

Authors and Affiliations

  1. 1.Department of Radiology, Division of Nuclear Medicine and Molecular ImagingBoston Children’s Hospital and Harvard Medical SchoolBostonUSA
  2. 2.Department of RadiologyBrigham and Women’s Hospital and Harvard Medical SchoolBostonUSA

Personalised recommendations