Pediatric Radiology

, Volume 47, Issue 12, pp 1638–1647 | Cite as

Image quality at synthetic brain magnetic resonance imaging in children

  • So Mi Lee
  • Young Hun Choi
  • Jung-Eun Cheon
  • In-One Kim
  • Seung Hyun Cho
  • Won Hwa Kim
  • Hye Jung Kim
  • Hyun-Hae Cho
  • Sun-Kyoung You
  • Sook-Hyun Park
  • Moon Jung Hwang
Original Article



The clinical application of the multi-echo, multi-delay technique of synthetic magnetic resonance imaging (MRI) generates multiple sequences in a single acquisition but has mainly been used in adults.


To evaluate the image quality of synthetic brain MR in children compared with that of conventional images.

Materials and methods

Twenty-nine children (median age: 6 years, range: 0–16 years) underwent synthetic and conventional imaging. Synthetic (T2-weighted, T1-weighted and fluid-attenuated inversion recovery [FLAIR]) images with settings matching those of the conventional images were generated. The overall image quality, gray/white matter differentiation, lesion conspicuity and image degradations were rated on a 5-point scale. The relative contrasts were assessed quantitatively and acquisition times for the two imaging techniques were compared.


Synthetic images were inferior due to more pronounced image degradations; however, there were no significant differences for T1- and T2-weighted images in children <2 years old. The quality of T1- and T2-weighted images were within the diagnostically acceptable range. FLAIR images showed greatly reduced quality. Gray/white matter differentiation was comparable or better in synthetic T1- and T2-weighted images, but poorer in FLAIR images. There was no effect on lesion conspicuity. Synthetic images had equal or greater relative contrast. Acquisition time was approximately two-thirds of that for conventional sequences.


Synthetic T1- and T2-weighted images were diagnostically acceptable, but synthetic FLAIR images were not. Lesion conspicuity and gray/white matter differentiation were comparable to conventional MRI.


Brain Children Image quality Magnetic resonance imaging Multi-echo multi-delay magnetic resonance imaging Neonates Synthetic imaging 


Compliance with ethical standards

Conflicts of interest



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Copyright information

© Springer-Verlag Berlin Heidelberg 2017

Authors and Affiliations

  • So Mi Lee
    • 1
  • Young Hun Choi
    • 2
  • Jung-Eun Cheon
    • 2
  • In-One Kim
    • 2
  • Seung Hyun Cho
    • 1
  • Won Hwa Kim
    • 1
  • Hye Jung Kim
    • 1
  • Hyun-Hae Cho
    • 3
  • Sun-Kyoung You
    • 4
  • Sook-Hyun Park
    • 5
  • Moon Jung Hwang
    • 6
  1. 1.Department of RadiologyKyungpook National University HospitalDaeguSouth Korea
  2. 2.Department of Radiology and Institute of Radiation MedicineSeoul National University College of MedicineSeoulRepublic of Korea
  3. 3.Department of RadiologyEwha Womans University Mokdong HospitalSeoulSouth Korea
  4. 4.Department of RadiologyChungnam National University HospitalDaejeonSouth Korea
  5. 5.Department of PediatricsKyungpook National University Hospital,DaeguSouth Korea
  6. 6.MR Applications and WorkflowGE HealthcareSeoulSouth Korea

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