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Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major

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Abstract

Calcineurin inhibitor-induced pain syndrome is an entity recognized in patients on immunosuppressive therapy after transplantation. Diagnosis is characterized by onset of pain beginning in the setting of an elevated calcineurin-inhibitor trough level. Reducing the medication dose relieves symptoms. Imaging findings can be nonspecific, including bone marrow edema and periosteal reaction. We present the unique case of calcineurin inhibitor-induced pain syndrome in a child and review the imaging findings.

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Authors and Affiliations

  1. Department of Radiology, Columbia University Medical Center, Morgan Stanley Children’s Hospital, 3959 Broadway, CHONY 3N, New York, NY, 10032, USA

    Rama S. Ayyala, Staci D. Arnold, Monica Bhatia & Jahannaz Dastgir

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  1. Rama S. Ayyala
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  2. Staci D. Arnold
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  3. Monica Bhatia
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  4. Jahannaz Dastgir
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Correspondence to Rama S. Ayyala.

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Ayyala, R.S., Arnold, S.D., Bhatia, M. et al. Imaging findings in a child with calcineurin inhibitor-induced pain syndrome after bone marrow transplant for beta thalassemia major. Pediatr Radiol 46, 1618–1621 (2016). https://doi.org/10.1007/s00247-016-3644-5

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  • DOI: https://doi.org/10.1007/s00247-016-3644-5

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