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Image-guided percutaneous core needle biopsy of soft-tissue masses in the pediatric population

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Abstract

Background

A paucity of literature describes the use of imaged-guided percutaneous core needle biopsy for the diagnosis and characterization of pediatric soft-tissue masses and lesions.

Objective

To retrospectively determine whether image-guided percutaneous core needle biopsy is adequate for diagnosing and characterizing benign and malignant pediatric soft-tissue masses and lesions.

Materials and methods

We identified children (≤18 years old) who underwent US- or CT-guided percutaneous core needle biopsy of a soft-tissue mass or other lesion between January 2012 and March 2014. Using medical records, we documented the following data: age and gender, site of the mass or lesion, size and number of biopsy specimens, whether the biopsy procedure was diagnostic, whether sufficient tissue was obtained for necessary ancillary testing (e.g., cytogenetic evaluation), and whether there was a procedural complication within 1 week.

Results

One hundred eight soft-tissue masses or lesions were biopsied under imaging guidance in 84 children; 39 (46%) were girls. Mean age ± standard deviation (SD) was 12.1 ± 5.1 years (range 6 months to 18 years). Of these procedures, 105/108 (97%) were diagnostic; 82/108 (76%) were US-guided; 87/108 (81%) were performed using a 17-gauge introducer needle/18-gauge biopsy instrument. The mean number ± SD of core needle biopsy specimens obtained was 8.9 ± 5.0. For newly diagnosed malignancies, adequate tissue was obtained for ancillary testing in 28/30 (93%) masses. One minor complication was documented.

Conclusion

Image-guided percutaneous core needle biopsy of pediatric soft-tissue masses is safe, has a high diagnostic rate, and provides sufficient tissue for ancillary testing.

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Authors and Affiliations

  1. Department of Radiology, Children’s Hospital of Michigan, Wayne State University School of Medicine, Detroit, MI, USA

    Terrence Metz

  2. Department of Pathology, C.S. Mott Children’s Hospital, University of Michigan Health System, Ann Arbor, MI, USA

    Amer Heider

  3. Department of Radiology, Children’s National Medical Center, George Washington University School of Medicine and Health Sciences, Washington, DC, USA

    Ranjith Vellody

  4. Section of Pediatric Surgery, C.S. Mott Children’s Hospital, University of Michigan Health System, Ann Arbor, MI, USA

    Marcus D. Jarboe & Erika A. Newman

  5. Department of Radiology, C.S. Mott Children’s Hospital, University of Michigan Health System, Ann Arbor, MI, USA

    Marcus D. Jarboe, Joseph J. Gemmete, Jason J. Grove & Ethan A. Smith

  6. Department of Pediatrics, Division of Pediatric Hematology/Oncology, C.S. Mott Children’s Hospital, University of Michigan Health System, Ann Arbor, MI, USA

    Rajen Mody

  7. Department of Radiology,Cincinnati Children’s Hospital Medical Center,, University of Cincinnati College of Medicine, 3333 Burnet Ave., ML 5031, Cincinnati, OH, 45229-3039, USA

    Jonathan R. Dillman

Authors
  1. Terrence Metz
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  2. Amer Heider
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  3. Ranjith Vellody
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  4. Marcus D. Jarboe
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  5. Joseph J. Gemmete
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  6. Jason J. Grove
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  7. Ethan A. Smith
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  8. Rajen Mody
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  9. Erika A. Newman
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  10. Jonathan R. Dillman
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Corresponding author

Correspondence to Jonathan R. Dillman.

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Metz, T., Heider, A., Vellody, R. et al. Image-guided percutaneous core needle biopsy of soft-tissue masses in the pediatric population. Pediatr Radiol 46, 1173–1178 (2016). https://doi.org/10.1007/s00247-016-3571-5

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  • DOI: https://doi.org/10.1007/s00247-016-3571-5

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