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Imaging of acute and subacute toxicities of cancer therapy in children

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Abstract

Effective cancer therapies have resulted in significant improvement in survival. However, treatment-related acute and subacute complications are a cause of significant morbidity and mortality. Effects of cancer therapy in children can be seen early in the survival period or later in life in almost all organ systems of the body. Many of these conditions are evaluated by imaging and some are diagnosed based on characteristic imaging features. This article aims to discuss acute and subacute toxicities of cancer therapy in children involving multiple organ systems, pulmonary, gastrointestinal, hepatobiliary, genitourinary and musculoskeletal systems with emphasis on those in which imaging plays a role in diagnosis or management. We also discuss the role of imaging and choice of imaging modalities in these conditions.

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Authors and Affiliations

  1. Department of Diagnostic Imaging, The Hospital For Sick Children and University of Toronto, 555 University Ave., Toronto, ON, M5G 1X8, Canada

    Govind B. Chavhan

  2. Department of Medical Imaging, Royal University Hospital, Saskatoon, SK, Canada

    Paul S. Babyn

  3. Division of Hematology/Oncology, Department of Pediatrics, The Hospital For Sick Children and University of Toronto, Toronto, ON, Canada

    Paul C. Nathan

  4. Department of Diagnostic Imaging and Department of Oncology, St. Jude Children’s Research Hospital, Memphis, TN, USA

    Sue C. Kaste

  5. Department of Radiology, University of Tennessee School of Health Sciences Memphis, Memphis, TN, USA

    Sue C. Kaste

Authors
  1. Govind B. Chavhan
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  2. Paul S. Babyn
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  3. Paul C. Nathan
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  4. Sue C. Kaste
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Correspondence to Govind B. Chavhan.

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Chavhan, G.B., Babyn, P.S., Nathan, P.C. et al. Imaging of acute and subacute toxicities of cancer therapy in children. Pediatr Radiol 46, 9–20 (2016). https://doi.org/10.1007/s00247-015-3454-1

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